Creating organoids from vestibular schwannoma tissue
Vestibular Schwannoma Stem Cell Organoids
This study is trying to create tiny models of vestibular schwannoma tumors from surgery samples to see how they relate to patient outcomes and better understand the tumor's biology.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Maastricht Radiation Oncology Academic / other |
| Locations | 2 sites (Maastricht, Limburg and 1 other locations) |
| Trial ID | NCT05786144 on ClinicalTrials.gov |
What this trial studies
This project involves collecting tissue from patients undergoing surgery for suspected vestibular schwannoma, a type of tumor affecting the auditory nerve. The remaining tissue, after sufficient samples are taken for diagnosis, will be used to create tumor stem cell organoids, which have not been previously described for this condition. The study aims to evaluate the correlation between the effects observed in these organoids and the actual patient outcomes, potentially providing valuable insights into the biology of vestibular schwannoma. Blood samples will also be collected to compare normal DNA with tumor DNA, without requiring additional interventions.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who have an MRI indicating suspicion of vestibular schwannoma and are scheduled for surgery.
Not a fit: Patients who refuse to participate or are younger than 18 years will not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with vestibular schwannoma.
How similar studies have performed: While the use of organoids in tumor research is established, the specific application to vestibular schwannoma is novel and has not been previously tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * MRI with suspicion for vestibular schwannoma * Indication for surgery in the skull base committee * 18 years or older Exclusion Criteria: * Refusal to participate * Younger than 18 years * Incapacitated
Where this trial is running
Maastricht, Limburg and 1 other locations
- Maastro — Maastricht, Limburg, Netherlands (Recruiting)
- Maastricht University Medical Center — Maastricht, Limburg, Netherlands (Recruiting)
Study contacts
- Principal investigator: Koos Hovinga — Maastricht University Medical Center
- Study coordinator: Chantal Overhof, Bec.
- Email: chantal.overhof@maastro.nl
- Phone: +31 88 4455863
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.