Creating organoids from head and neck cancer tumors to test new treatments

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on developing organoid cultures from squamous cell carcinoma tumors of the head and neck to evaluate their response to innovative therapies. By utilizing tumor and blood samples from patients undergoing surgery, the research aims to create models that closely resemble the original tumors. These organoids can potentially predict treatment responses and guide therapeutic decisions, bridging the gap between traditional cell lines and patient-derived xenografts. The study seeks to enhance our understanding of tumor progression and treatment efficacy in head and neck cancers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient over 18 years of age;
* Patient with squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx or larynx, classified T3Nx or T4Nx or T2N +, not previously treated;
* Patient to be treated by surgery;
* Patient affiliated to a social security scheme;
* No opposition to participate in the study

Exclusion Criteria:

* Pregnant woman ;
* Persons deprived of their liberty or under guardianship (including curatorship);
* History of malignant pathology preceding inclusion (apart from basal cell carcinomas of the skin and carcinomas in situ of the cervix treated surgically) or concomitant at inclusion (synchronous tumor)

Where it's running

• Centre François Baclesse
  Caen, France Recruiting
• CHU de Caen
  Caen, France Recruiting

Study contacts

• Study coordinator: Vianney BASTIT, MD
• Email: bastit-v@chu-caen.fr
• Phone: + 33 2 31 06 54 37

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.