Creating human sperm in a lab using testicular organoids

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to investigate the potential for producing human sperm in vitro by maintaining a laboratory-cultured adult testicular environment. Researchers will analyze genetic factors linked to male infertility and failed sperm production by comparing genomic profiles of fertile and infertile males. The study involves constructing an 'organ-on-a-chip' model called iTestis to support the cultivation of spermatogonial stem cells and assess whether human spermatogenesis can be recreated outside the body. Participants will provide testicular and skin tissue samples for this innovative approach.

Why it matters

Who can join: the full rules

Inclusion Criteria: Group 1 (Fertile Control)

* Male sex of reproductive age (between 18 - 60 years old).
* Evidence of fertility or normal spermatogenesis.
* Will undergo study procedures in conjunction with their planned fertility or infertility procedures performed for clinical purposes.

Inclusion Criteria: Group 2 and 3 (Infertile)

* Male sex of reproductive age (between 18 - 60 years old).
* Males with evidence of \>1 year of infertility.
* Posesses diagnosis of azoospermia is on clinical evaluation.
* Will undergo study procedures in conjunction with their planned fertility or infertility procedures performed for clinical purposes.

Exclusion Criteria:

\- The lack of diagnosis of fertility or infertility, and lack of testicles.

Where it's running

• The Turek Clinic
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Paul J Turek, MD — Chief Medical Officer
• Study coordinator: Erica S Godart, BS
• Email: ericagodart@gmail.com
• Phone: 4244579202

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.