Creating a new index to help patients safely stop using mechanical ventilation
Development of a Multimodal Index to Improve the Predictive Value of Success in Weaning From Mechanical Ventilation
This study is testing a new way to help critically ill patients safely come off mechanical ventilation by monitoring their breathing and other factors to find the best time to stop support.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 126 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Corporacion Parc Tauli Academic / other |
| Locations | 1 site (Sabadell, Barcelona) |
| Trial ID | NCT04554095 on ClinicalTrials.gov |
What this trial studies
This study aims to develop a multimodal index that enhances the prediction of successful weaning from mechanical ventilation in critically ill patients. By continuously monitoring various parameters, including respiratory metrics and patient-ventilator interactions, the study seeks to identify the optimal timing for withdrawing mechanical support. The goal is to reduce the rates of weaning failure and associated complications, ultimately improving patient outcomes in intensive care settings.
Who should consider this trial
Good fit: Ideal candidates for this study are critically ill patients who have been on mechanical ventilation for more than 24 hours and meet specific weaning criteria.
Not a fit: Patients with tracheostomy or those with neurological conditions affecting the brainstem may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of weaning failure and its associated complications, leading to better recovery outcomes for patients.
How similar studies have performed: While the approach of developing a multimodal index for weaning from mechanical ventilation is innovative, similar studies have shown varying degrees of success in improving weaning outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with MV\> 24 hours. * Patients with orotracheal tube. * Patients who meet the classic criteria of weaning from the MV defined as: Improvement or resolution of the cause required for MV. PaO2\> 60mmHg with FiO2≤0.4 and PEEP ≤8cm H2O. Glasgow Coma Score\> 10 Temperature \<38 ° C. Hemoglobin\> 8g / dL No need for vasoactive drugs or at doses \<5μg / kg / min Obtaining informed consent. Exclusion Criteria: * Tracheostomy patients. * Patients with neurological pathology with involvement of the brainstem.
Where this trial is running
Sabadell, Barcelona
- Candelaria De Haro — Sabadell, Barcelona, Spain (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.