Creating a database to understand the effects of KCNH2 gene variants in Long QT Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to build a comprehensive diagnostic and prognostic database focused on the effects of variants in the KCNH2 gene, which is linked to Long QT Syndrome. By utilizing Next Generation Sequencing, the study will analyze numerous KCNH2 variants to determine their functional significance and impact on heart rhythm disorders. The goal is to enhance understanding of these variants' pathogenicity, which is essential for accurate diagnosis and treatment planning for affected patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients carrier of a mutation in KCNH2 gene

Exclusion Criteria:

* Patients who refuse to take part to research

Where it's running

• Nantes university hospital
  Nantes, Loire-atlantique, France Recruiting
• Hôpital Bichat - Claude Bernard
  Paris, France Recruiting

Study contacts

• Study coordinator: Vincent Probst, PUPH
• Email: vincent.probst@chu-nantes.fr
• Phone: 0240165279

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• AI-powered ECG tools to detect deadly heart rhythms and ICI-related myocarditis

  Researchers are testing AI-powered analysis of ECG data to see if it can help flag dangerous arrhythmias and myocarditis in people who may be affected by immune checkpoint inhibitors.

  Recruiting Groupe Hospitalier Pitie-Salpetriere · Paris · NCT07644715

• Monitoring Long QT Syndrome with Wearable Devices

  This study tests if using wearable devices to track heart activity can help adults with Long QT syndrome manage their condition better.

  Recruiting Queen Mary University of London · London · NCT06887387

• Registry for hereditary cardiovascular diseases in Brazil

  This study is trying to create a registry of Brazilian patients with hereditary heart diseases to see how common certain genetic changes are in people with these conditions.

  Recruiting at 27 sites Hospital do Coracao · Rio Branco, Acre and 26 other locations · NCT06546137

• Long-term outcomes for patients with cardiac arrhythmias

  This study looks at how well treatments for heart rhythm problems work over time and what factors might affect their success for patients with conditions like atrial fibrillation and ventricular tachycardia.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT05521451

• Comparing direct and indirect methods for screening family members at risk for genetic conditions

  This study is testing two ways to reach out to family members at risk for Long QT Syndrome and Familial Hypercholesterolemia to see which method helps them get screened better, while also offering free genetic testing and counseling.

  Recruiting University of Maryland, Baltimore · Lancaster, Pennsylvania · NCT05348564

• Comparing continuous and intermittent heart monitoring methods

  This study is testing a new continuous heart monitoring patch to see if it works better than regular heart tests for patients with certain heart conditions who are taking medications that might cause problems.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT04336644

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.