Creating a database of eye images using a holographic laser

Creation of a Database of Images of the Eye With the Holographic Doppler Laser

This study is trying to create a detailed collection of eye images using a new laser to help understand blood flow in the eyes of both patients with eye problems and those without any known issues.

Quick facts

• Study type: Observational
• Enrollment: 123 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Fondation Ophtalmologique Adolphe de Rothschild (Research network)
• Drugs / interventions: radiation
• Locations: 1 site (Paris)
• Trial ID: NCT06644196 on ClinicalTrials.gov

What this trial studies

This study aims to create a comprehensive database of images and videos of the eye's fundus using a new holographic Doppler laser device. The device is designed to visualize and quantify blood flow in the eye, which is crucial for understanding various retinal pathologies of vascular origin. Participants will undergo imaging procedures at the Hôpital Fondation Adolphe de Rothschild, where the second prototype of the laser will be utilized. The study focuses on patients with known ocular pathologies as well as those without any known eye issues, ensuring a broad understanding of eye vascular health.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older with either known ocular pathologies or no significant eye issues.

Not a fit: Patients with severe ocular conditions that prevent imaging or those who do not meet the age or consent criteria may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance the diagnosis and treatment of retinal vascular diseases, leading to better patient outcomes.

How similar studies have performed: While this approach is innovative, similar studies using advanced imaging techniques have shown promise in improving the understanding of retinal conditions.

Eligibility criteria

Inclusion Criteria:

For all participants:

* Age ≥ 18 years
* Having received informed information about the study and having signed a consent to participate in the study
* Affiliated or beneficiary of social insurance

For participants with no known ocular pathology:

\- No known ocular pathology other than a refractive disorder

For patients with optic nerve pathology:

\- Patient undergoing ophthalmology consultation for optic nerve pathology in at least one eye (examples: glaucoma, optic neuritis, hereditary optic nerve diseases)

For patients with retinal and/or choroidal pathology:

\- Patients undergoing ophthalmology consultations for retinal and/or choroidal pathology in at least one eye (examples: diabetic retinopathy, age-related macular degeneration).

For patients with retinal vascular pathology:

\- Patient undergoing ophthalmology consultation for retinal vascular pathology in at least one eye (e.g. central retinal artery occlusion, central retinal vein occlusion, ocular ischemia syndrome).

Exclusion Criteria:

* Inability to maintain a stable sitting position
* Contraindications to holographic doppler laser :

  * implanted medical electronic device (pacemaker or other)
  * history of photosensitivity.
  * received photo-dynamic therapy (PDT) within the last 3 months.
  * viral conjunctivitis or any other infectious disease.
  * skin lesions on the neck or forehead, not allowing contact with a chin strap
  * patients at high risk of damage from optical radiation (e.g. aphakic patients, or patients with reduced sensitivity to light due to disease of the back of the eye).

Where this trial is running

Paris

• Hôpital Fondation A. de Rothschild — Paris, France (Recruiting)

Study contacts

• Principal investigator: Raphaël Lejoyeux, Dr — Hôpital Fondation Adolphe de Rothschild
• Study coordinator: Amélie Yavchitz

Conditions Vessels of the Eye Fundus