Creatine supplementation for treating homocystinuria
Creatine Supplementation for CBS-related Homocystinuria: a Proof-of-concept Study in Healthy Adults
This study is testing if taking creatine can help lower homocysteine levels in healthy adult men who have a rare condition called homocystinuria.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 6 (estimated) |
| Ages | 19 Years to 40 Years |
| Sex | Male |
| Sponsor | University of British Columbia Academic / other |
| Locations | 1 site (Vancouver, British Columbia) |
| Trial ID | NCT06495567 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the effects of creatine supplementation on reducing homocysteine levels in healthy adult men. Homocystinuria is a rare metabolic disorder caused by the inability to break down homocysteine, leading to toxic accumulation. The researchers will administer high doses of creatine and utilize stable isotope techniques to measure changes in methionine turnover and homocysteine production. The ultimate goal is to assess whether creatine could serve as an alternative treatment for individuals with homocystinuria.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adult men with a normal body weight and no concurrent illnesses.
Not a fit: Patients with metabolic, neurological, genetic, or immune disorders, as well as those with food allergies or who are following non-traditional diets, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new treatment option for patients with homocystinuria, potentially improving their quality of life.
How similar studies have performed: While this approach is novel in the context of homocystinuria, stable isotope techniques have been successfully used in other metabolic studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cis-male * Men who are classified as normal body weight and BMI (18.5-25kg/m2) * Free of any concurrent illness (cold, flu, vomiting etc.) * Not be claustrophobic (we will place a clear hood, which can easily be removed, over your head for approximately 20 min to measure your energy expenditure) * Not be enrolled in any other research studies (as this may affect our study results) Exclusion Criteria: * Men not in good health or have a metabolic, neurological, genetic, or immune disorder, including diabetes, hypoglycemia, hypertension and current or past history of kidney disease * Men who have food allergies/sensitivities/intolerances to egg, corn, diary etc. * Men who have current or recent past history of ingesting creatine supplements * Men who are smokers * Men who are following a non-traditional dietary pattern (e.g. Keto diet, Atkins diet, paleo diet, intermittent fasting, strict vegan, calorie restricted diet etc.)
Where this trial is running
Vancouver, British Columbia
- BC Children's Hospital Research Institute, University of British Columbia — Vancouver, British Columbia, Canada (Recruiting)
Study contacts
- Principal investigator: Rajavel Elango, PhD — University of British Columbia
- Study coordinator: Deepa Subramonian, PhD
- Email: deepa.subramonian@cw.bc.ca
- Phone: 604-875-2345
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.