Corticosteroid injection to reduce pain after hip replacement
Periarticular Administration of Dexamethasone to Improve Post-operative Pain, Function, Nausea, Hospitalization Length, and Risk of Complications in Patients Undergoing Hip Arthroplasty - A Randomized Trial
This study tests if a steroid injection during hip replacement surgery can help patients feel less pain afterward and leave the hospital sooner.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 110 (estimated) |
| Ages | 50 Years to 90 Years |
| Sex | All |
| Sponsor | Ente Ospedaliero Cantonale, Bellinzona Academic / other |
| Locations | 1 site (Lugano) |
| Trial ID | NCT05023369 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of periarticular corticosteroid injection during hip replacement surgery to reduce postoperative pain and shorten hospital stays. The intervention involves administering dexamethasone, a steroid, to patients undergoing unilateral cemented hip endoprosthesis for femoral neck fractures. The goal is to improve pain management, decrease the need for analgesics, and ultimately reduce healthcare costs associated with prolonged hospitalization. The study aims to build on previous findings that suggest steroid supplementation can enhance recovery outcomes.
Who should consider this trial
Good fit: Ideal candidates are patients aged 50-90 with a BMI between 18.5 and 35 who are undergoing unilateral cemented hip endoprosthesis for femoral neck fractures.
Not a fit: Patients with contraindications to steroids, active steroid therapy, or significant comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve pain management and recovery times for patients undergoing hip replacement surgery.
How similar studies have performed: Previous studies have shown positive outcomes with steroid supplementation in postoperative pain management, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing unilateral cemented hip endoprosthesis for femoral neck fracture * Patients aged 50-90 years old * Patients with a BMI \>18.5 and \<35 * Patients able to provide informed consent and follow all the study procedures as indicated by the protocol * Informed Consent as documented by signature Exclusion Criteria: * Contraindications to steroids * Revision endoprosthesis * Active steroid or immunosuppressive therapy in the last 30 days before the operation * Pregnant or breast-feeding women * Presence of other clinically significant concomitant disease states (ASA IV) * Uncontrolled diabetes mellitus * Contraindications to NSAIDs * Chronic systemic diseases as immunodeficiency, autoimmune disease (Systemic Lupus Erythematosus, SLE), gout, rheumatic arthritis * Known or suspected non-compliance, drug or alcohol abuse * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant. * Participation in another study with investigational drug within the 30 days preceding and during the present study * Previous enrolment into the current study * Enrolment of the investigator, his/her family members, employees and other dependent persons.
Where this trial is running
Lugano
- Christian Candrian — Lugano, Switzerland (Recruiting)
Study contacts
- Principal investigator: Christian MD Candrian, Prof. — Eoc
- Study coordinator: Christian MD Candrian, Prof.
- Email: Gabriela.Induni-Lang@eoc.ch
- Phone: 0041918117029
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.