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COPD prevalence and short-term outcomes in people with coronary heart disease, atrial fibrillation, or chronic heart failure

The Prevalence, Disease Burden and Prognosis of COPD in Patients With Cardiovascular Diseases -A Multi-center, Prospective, Interventional Study (PRECEDE)

NA · AstraZeneca · NCT06909773

This project will test whether checking for COPD and using coordinated cardiopulmonary care improves short-term outcomes for people aged 40 and older who have coronary heart disease, atrial fibrillation, or chronic heart failure.

Quick facts

PhaseNA
Study typeInterventional
Enrollment3000 (estimated)
Ages40 Years and up
SexAll
SponsorAstraZeneca (industry)
Locations84 sites (Anqing and 83 other locations)
Trial IDNCT06909773 on ClinicalTrials.gov

What this trial studies

This multi-center, prospective interventional study will enroll about 3,000 adults aged 40 or older with one of three cardiovascular conditions (coronary heart disease, atrial fibrillation, or chronic heart failure), with roughly 1,000 participants per cohort. Participants will undergo spirometry to identify COPD and sites will implement guideline-based education and care to promote cardiopulmonary co-management. Investigators will describe COPD prevalence across the cardiovascular cohorts and track short-term clinical outcomes following the guideline implementation. The study is being conducted across multiple sites in China to reflect real-world implementation of co-management practices.

Who should consider this trial

Good fit: Ideal candidates are adults aged 40 or older with a diagnosis of coronary heart disease, atrial fibrillation, or chronic heart failure who can perform spirometry and provide informed consent.

Not a fit: Patients under 40, those who cannot perform spirometry, pregnant or lactating women, people with major comorbid conditions that preclude participation, or those unable to give consent are unlikely to benefit from joining this project.

Why it matters

Potential benefit: If successful, the approach could lead to earlier detection of COPD in people with heart disease and improved short-term outcomes through coordinated cardiopulmonary care.

How similar studies have performed: Previous research shows COPD is common among people with cardiovascular disease and that integrated care can improve some outcomes, but evidence that guideline-driven cardiopulmonary co-management reliably improves short-term prognosis is limited and mixed.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Give signed written informed consent to participate.
2. At least 40 years of age at baseline visit.
3. Previous or newly diagnosed by at least one of the 3 types of CVD which are,

   * Coronary heart disease ( CHD )
   * Atrial fibrillation (AF )
   * Chronic heart failure ( CHF )
4. Subjects have no absolute contraindications to spirometry testing.
5. Subjects have the cognitive ability to conduct questionnaires after e valuated by investigators.

Exclusion Criteria:

1. Significant diseases or conditions, which, in the opinion of the investigator, may put the subject at risk because of participation in the study or may influence either the results of the study or the subject's ability to participate in the study.
2. Women who are pregnant or lactating or are planning to become pregnant, or women of childbearing potential who are not using an acceptable method of contraception.
3. Subjects who are not able to provide written informed consent.
4. Treatment with investigational study drug or device in another clinical study within the last 30 days or five half lives prior to baseline visit , whichever is longer.

Where this trial is running

Anqing and 83 other locations

+34 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Cardiovascular Diseases

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.