Cooling and dilution during heart attack treatment to protect the heart

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot trial involves 60 patients with ST-Elevation Myocardial Infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) at Harefield Hospital. The study aims to assess the feasibility and safety of using trans-coronary cooling and dilution during PCI to reduce the size of myocardial infarction. Patients will be randomly assigned to receive either the cooling intervention or standard care, with evaluations of coronary flow, microvascular function, and myocardial salvage through MRI. The study will also analyze blood biomarkers before and after the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical ST-elevation myocardial infarction or equivalent (e.g. new onset LBBB)
* \<12 Hrs after symptom onset
* Thrombolysis in myocardial infarction (TIMI) 0-1 coronary flow in a target vessel

Exclusion Criteria:

* History of severe asthma
* Pregnancy
* Severe concomitant disease or conditions with a life expectancy of less than one year.

Where it's running

• Harefield Hospital
  Uxbridge, United Kingdom Recruiting

Study contacts

• Principal investigator: Miles C Dalby, MD — Royal Brompton & Harefield NHS Foundation Trust
• Study coordinator: Miles C Dalby, MD
• Email: m.dalby@rbht.nhs.uk
• Phone: +441895 823737

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.