Controlling blood uric acid after pancreatic cancer surgery to improve survival

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a retrospective observational analysis of patients with pathologically confirmed primary pancreatic cancer who underwent radical resection (pancreaticoduodenectomy or distal pancreatectomy) at a single center in Lanzhou, Gansu. Investigators will extract preoperative and postoperative serum uric acid (SUA) measurements from medical records and correlate changes in SUA with overall survival and postoperative outcomes, using available clinical data to adjust for confounders. Patients with conditions or treatments that substantially affect uric acid (for example gout, chronic kidney disease, or long-term urate-lowering therapy) are excluded to reduce bias. The study aims to determine whether perioperative changes in SUA can serve as a prognostic marker after pancreatic cancer resection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with pathologically confirmed pancreatic cancer (primary)
* Patients who underwent Radical resection of pancreatic cancer（Pancreaticoduodenectomy or Distal pancreatectomy）
* The postoperative survival time was at least 6 weeks

Exclusion Criteria:

* No surgery was performed, or only palliative surgery/ biopsy was performed
* Patients who underwent emergency hemodialysis or plasma exchange after surgery
* History of gout or long-term urate-lowering therapy, such as allopurinol
* Patients are missing follow-up data
* Hydrochlorothiazide and furosemide were used
* Chronic kidney disease
* Oncolytic syndrome
* Hemolytic anemia
* Lead poisoning
* Hyperparathyroidism
* Hypothyroidism
* A tyrosinase inhibitor was used
* Patients with nonpancreatic primary tumors
* Pregnant or postpartum women.

Where it's running

• Hepatopancreatobiliary Surgery Institute of Gansu Province
  Lanzhou, Gansu, China Recruiting

Study contacts

• Principal investigator: Wenbo Meng, M.D. Ph. D. — Hepatopancreatobiliary Surgery Institute of Gansu Province
• Study coordinator: Wenbo Meng, M.D. Ph. D.
• Email: mengwb@163.com
• Phone: 13919177177

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.