Controlling blood pressure after preeclampsia to improve heart health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the effects of intensive postpartum blood pressure control on cardiovascular health in women who experienced hypertensive disorders during pregnancy. A total of 618 postpartum patients will be randomly assigned to receive either intensive blood pressure management or usual care in the first six weeks after delivery. The intervention involves initiating nifedipine extended-release for those with elevated blood pressure, while the control group will start treatment at a higher threshold. Participants will undergo various cardiovascular assessments and biomarker collections at baseline, six weeks, and twelve months postpartum to determine the impact on hypertension and vascular function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Hypertensive disorders of pregnancy (HDP) diagnosis, specifically gestational hypertension, preeclampsia, eclampsia, or HELLP syndrome, according to ACOG guidelines
* Postpartum day 0-4
* Age ≥ 18 years
* Able to communicate in English or in Spanish
* Has an established OBGYN at an MCW or NU health system practice that has access to Epic electronic medical records.

Exclusion Criteria:

* Pre-gestational hypertension
* Type 1 or type 2 diabetes mellitus
* Admitted to intensive care unit at the time of screening
* Diagnosed with HDP during postpartum readmission after discharge from delivery hospitalization
* Getting discharged on the day of screening
* Known allergy or contraindication to nifedipine ER
* Inability or unwillingness to provide informed consent
* Already taking long-acting antihypertensive medication for standard care
* Maternal conditions that impact study outcomes: sickle cell disease, systemic lupus erythematosus

Where it's running

• Northwestern University
  Chicago, Illinois, United States Recruiting
• Medical College of Wisconsin
  Milwaukee, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Anna Palatnik, MD — Medical College of Wisconsin
• Study coordinator: Alyssa M Hernandez, DO
• Email: alyhernandez@mcw.edu
• Phone: 4148055285

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Two phone-based approaches to manage high blood pressure after delivery

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• Using low-dose aspirin after preeclampsia to improve recovery

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  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06281665

• Improving heart disease prevention after a pregnancy with high blood pressure

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  Recruiting University of Utah · Salt Lake City, Utah · NCT05826925

• Preventing pre-eclampsia with low-dose aspirin in women after frozen embryo transfer

  This study is testing if taking low-dose aspirin can help prevent pre-eclampsia in pregnant women who have had a frozen embryo transfer.

  Recruiting Phase 3 Centre Hospitalier Universitaire de Liege · Liège · NCT05460416

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.