Contrast perfusion ultrasound to help diagnose heart attacks in patients with suspected NSTEMI

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This intervention compares contrast-enhanced transthoracic myocardial perfusion ultrasound with coronary angiography and cardiac MRI in adults admitted for suspected NSTEMI. Eligible patients have elevated troponin above the 99th percentile and new segmental wall-motion abnormalities or ECG repolarization changes and are scheduled for angiography within 72 hours. The ultrasound exam uses an approved microbubble contrast agent to visualize myocardial perfusion and may help distinguish true infarction from mimics such as myocarditis or stress cardiomyopathy. Results will be compared against angiographic findings and MRI when available to determine diagnostic performance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient over 18 years of age
* Hospitalised in cardiology as an emergency for acute coronary syndrome without ST segment elevation with indication for coronary angiography within 72 hours of admission
* Not yet undergone coronary angiography.
* Troponin \>99th percentile, i.e. \>27ng/l (troponin I, hypersensitive, Abbott)
* With de novo segmental kinetic disorder on TTE or ECG repolarisation disorder outside ST elevation
* Patient affiliated with a health insurance scheme
* French-speaking patient
* Patient who has given their free, informed and written consent

Exclusion Criteria:

Haemodynamically unstable patient: HR \> 100 and/or systolic blood pressure \< 90 mmHg and/or diastolic blood pressure \< 60 mmHg and/or oxygen saturation \< 92% in AA and/or clinical signs of hypoperfusion (mottling, cyanosis)

* Rhythmically unstable patient: sustained ventricular tachycardia, sudden death recovered.
* Patient with a known allergy to ultrasound contrast medium
* Patient with ST segment elevation.
* Patient with a contraindication to MRI.
* Patient with a caricatured picture of myocarditis (fever and/or significant biological inflammatory syndrome with CRP\>50mg/l)
* Patients already included in a type 1 interventional research protocol (RIPH1)
* Patients under guardianship or curatorship
* Patients deprived of their liberty
* Patients under judicial protection
* Pregnant or breastfeeding patients (negative pregnancy test for women of childbearing age)

Where it's running

• Hospital Paris Saint-Joseph
  Paris, Ilede France, France Recruiting

Study contacts

• Principal investigator: Yoann MOEUF, medical doctor — Hospital Paris Saint-Joseph
• Study coordinator: Yoann MOEUF, medical doctor
• Email: ymoeuf@ghpsj.fr
• Phone: +33 1 44 12 62 44

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.