Contrast-enhanced endobronchial ultrasound for lung lesions and chest lymph nodes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional single-center study uses contrast-enhanced endobronchial ultrasound (CE-EBUS) during EBUS-TBNA to record enhancement patterns of central pulmonary lesions and intrathoracic lymph nodes. Adult patients with CT or PET/CT findings suggesting central lung lesions or enlarged intrathoracic lymph nodes who are scheduled for diagnostic or staging EBUS-TBNA are enrolled. Contrast enhancement features on CE-EBUS images will be compared with pathological results from TBNA to determine diagnostic value. Standard exclusion criteria include contrast hypersensitivity and significant cardiac or pulmonary comorbidities that contraindicate contrast use or EBUS-TBNA.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>18 years old；
* Enlargement of at least one intrathoracic LN (short diameter \> 1 cm) or central parenchymal lung lesions adjacent to the airway detected on chest CT, or increased fluorodeoxyglucose uptake in at least one intrathoracic lymph node on PET / CT (standardized uptake value \> 2.5)；
* CP-EBUS-TBNA is required to determine the diagnosis or staging, the patient agreed to undergo CE-EBUS, and there were no contraindications to EBUS-TBNA;
* Patients who have good compliance and sign informed consent.

Exclusion Criteria:

* Patients with known hypersensitivity to ultrasound contrast components;
* Patients with severe pulmonary hypertension (pulmonary artery pressure \> 90 mmHg);
* Patients with angina pectoris, acute coronary syndrome, clinically unstable ischemic heart disease, heart failure, cardiac dysfunction, and cardiac disease with right-to-left shunting;
* Patients with uncontrolled essential hypertension and adults with respiratory distress syndrome;
* Pregnant or lactating women；
* Patients with contraindications to bronchoscopy；
* Patients with other conditions that, in the opinion of the investigator, make the patient unsuitable for the study.

Where it's running

• Shanghai Chest Hospital
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Jiayuan sun
• Email: jysun1976@163.com
• Phone: +1511 86-021-22200000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Shape-sensing robotic bronchoscopy to diagnose peripheral lung nodules

  This tests a shape-sensing robotic bronchoscopy to see if it can get tissue samples from adults in Korea with peripheral lung nodules.

  Recruiting Ulsan University Hospital · Ulsan · NCT07057648

• Diagnosing Peripheral Lung Lesions With Cryo Biopsies

  A study to see if cryo biopsies taken through a bronchoscope can better diagnose small lung lesions than the usual forceps biopsies in adults undergoing lung cancer workups.

  Recruiting Odense University Hospital · Næstved, Region Sjælland and 1 other locations · NCT06844344

• Comparing ultrasound and CT-guided lung biopsies for diagnosing lung lesions

  This study is testing whether ultrasound-guided lung biopsies are better or safer than CT-guided biopsies for diagnosing lung lesions in patients.

  Recruiting at 2 sites University Hospital of Ferrara · Ferrara and 1 other locations · NCT06412289

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.