Continuing versus stopping aspirin during non-surgical management of chronic subdural hematoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial assigns adults with chronic subdural hematoma who are already taking aspirin and managed conservatively to either continue aspirin or discontinue it while receiving standard non-surgical care. Participants receive routine conservative measures and close clinical and imaging follow-up to monitor for hematoma enlargement, neurological changes, or thromboembolic events. The study compares safety outcomes (hematoma growth, bleeding) and thrombotic complications between the two groups. Results are intended to inform individualized aspirin management when surgery is not indicated.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years, male or female;
* Confirmed diagnosis of chronic subdural hematoma (cSDH) by cranial CT and/or MRI;
* Intended for conservative management (i.e., no surgical evacuation indication at enrollment);
* Regular aspirin use at enrollment;
* Informed consent signed by the patient or legal representative.

Exclusion Criteria:

* Patients requiring emergency surgery to remove hematoma at enrollment;
* Concurrent use of other anticoagulants or antiplatelet agents that cannot be discontinued according to the study protocol;
* cSDH secondary to other diseases or conditions (e.g., excessive drainage from ventriculoperitoneal shunts, intracranial tumors);
* Active bleeding events or major cardiac events (e.g., acute myocardial infarction, unstable angina, or revascularization surgery) within 30 days prior to enrollment;
* Known bleeding disorders (e.g., hemophilia, severe thrombocytopenia);
* Individuals unable to provide informed consent or for whom completion of follow-up is anticipated to be difficult.

Where it's running

• Xuanwu Hospital Capital Medical University
  Beijing, China Recruiting
• Tianjin Medical University General Hospital
  Tianjin, China Recruiting

Study contacts

• Study coordinator: Tao Liu, MD
• Email: TLiu1@georgeinstitute.org.au
• Phone: +86-18302204804

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.