Connective tissue graft with or without L-PRF to thicken gum tissue around delayed dental implants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial compares two surgical approaches to increase buccal peri-implant mucosal thickness around delayed implants: connective tissue graft (CTG) alone versus CTG combined with leukocyte platelet-rich fibrin (L-PRF). Eligible adults with a single missing tooth in the incisor, canine, or premolar area and thin gingival phenotype (<2 mm) will receive one of the two treatments and have soft tissue thickness measured over follow-up. Patients with prior bone augmentation, smokers, or systemic conditions affecting healing are excluded. Outcomes focus on changes in mucosal thickness, peri-implant soft tissue health, and esthetic contour after implant restoration.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Patients between 18-60 years. 2. With thin gingival phenotype with a peri-implant mucosal thickness of less than 2mm28. With single missing tooth in the incisor, canine and premolar area. With the presence of two natural adjacent teeth and to not have a bone augmentation procedure before or during the dental implant.

  3\. Patient consent approval and signing 4. Medically free patients 5. Patients with good oral hygiene 6. Patients free from untreated periodontal disease

Exclusion Criteria:

* 1\. Smokers 2. Psychological problem 3. Pregnancy 4. Systemic disease 5. Poor oral hygiene 6. Patients who previously received radiation therapy of the jaws 7. Patients taking medications that affect healing.

Where it's running

• The British University in Egypt
  Cairo, Cairo Governorate, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.