Connective tissue graft with or without L-PRF to thicken gum tissue around delayed dental implants
Effectiveness of Connective Tissue Graft With and Without Leukocyte Platelet Rich Fibrin on Peri-implant Soft Tissue Thickness Around Delayed Implants in Patients With Thin Gingival Phenotype: A Randomized Controlled Clinical Trial
This trial will test whether adding leukocyte platelet-rich fibrin (L-PRF) to a connective tissue graft helps thicken the soft tissue around delayed implants in adults with a thin gingival phenotype.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 38 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | British University In Egypt Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Cairo, Cairo Governorate) |
| Trial ID | NCT07368621 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial compares two surgical approaches to increase buccal peri-implant mucosal thickness around delayed implants: connective tissue graft (CTG) alone versus CTG combined with leukocyte platelet-rich fibrin (L-PRF). Eligible adults with a single missing tooth in the incisor, canine, or premolar area and thin gingival phenotype (<2 mm) will receive one of the two treatments and have soft tissue thickness measured over follow-up. Patients with prior bone augmentation, smokers, or systemic conditions affecting healing are excluded. Outcomes focus on changes in mucosal thickness, peri-implant soft tissue health, and esthetic contour after implant restoration.
Who should consider this trial
Good fit: Adults 18–60 years old with a thin gingival phenotype (peri-implant mucosal thickness <2 mm), a single missing tooth in the incisor/canine/premolar region, good oral hygiene, and no need for bone augmentation are ideal candidates.
Not a fit: Smokers, patients with systemic diseases or prior jaw radiation, those on medications that impair healing, pregnant patients, or people with poor oral hygiene are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the combined CTG+L-PRF approach could lead to thicker, more stable peri-implant soft tissue with improved esthetics and potentially lower risk of peri-implant bone loss.
How similar studies have performed: Connective tissue grafting is an established method to thicken peri-implant mucosa and small studies suggest L-PRF can aid soft tissue healing, but high-quality randomized data combining CTG with L-PRF remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\. Patients between 18-60 years. 2. With thin gingival phenotype with a peri-implant mucosal thickness of less than 2mm28. With single missing tooth in the incisor, canine and premolar area. With the presence of two natural adjacent teeth and to not have a bone augmentation procedure before or during the dental implant. 3\. Patient consent approval and signing 4. Medically free patients 5. Patients with good oral hygiene 6. Patients free from untreated periodontal disease Exclusion Criteria: * 1\. Smokers 2. Psychological problem 3. Pregnancy 4. Systemic disease 5. Poor oral hygiene 6. Patients who previously received radiation therapy of the jaws 7. Patients taking medications that affect healing.
Where this trial is running
Cairo, Cairo Governorate
- The British University in Egypt — Cairo, Cairo Governorate, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.