Conditioning the Soleus Reflex in Adults with Cerebral Palsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study involves 12 adults with spastic cerebral palsy who will undergo a series of conditioning sessions aimed at reducing muscle spasticity. Participants will complete 6 baseline sessions followed by 24 conditioning sessions, where the soleus H reflex will be elicited to decrease its magnitude. Assessments will be conducted at baseline and after the intervention, with follow-ups at 2 weeks, 1 month, and 3 months. The goal is to explore a non-invasive method to improve motor function and reduce spasticity in individuals with cerebral palsy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 18 and above
2. Diagnosis of spastic Cerebral Palsy
3. Gross Motor Function Classification System level I-III
4. Stable medical background
5. Current medication will remain unchanged for 3 months
6. Provides informed consent
7. can walk at least 10 meters with or without assistive device
8. meets minimum study procedure requirements (elicitation of H-reflex).

Exclusion Criteria:

1. Pregnancy
2. uncontrolled diabetes
3. weak dorsiflexion
4. History of cardiac conditions
5. cognitive deficits that interfere with study procedure and steps for completion
6. Botox within 2 months of the study
7. H/O ankle surgeries in affected leg (Dorsal root rhizotomy etc.)
8. regular use of electrical stimulation to lower extremity muscles
9. Cochlear or metal implantations on body
10. No history of seizure after age 2 years
11. Current use of antiseizure medicines
12. Any metal or magnetic components in the head (surgical clips, metal work etc.)
13. Implanted device or cardiac pacemakers (applicable for DS8R too)
14. Skin disorders
15. Damaged skin (wounds, broken skin, or recent scar tissue)
16. Allergy to latex (tape)

Where it's running

• Burke Neurological Institute
  White Plains, New York, United States Recruiting

Study contacts

• Principal investigator: Kathleen Friel, PhD — Burke Neurological Institute
• Study coordinator: Devina Kumar, PhD
• Email: dek4004@med.cornell.edu
• Phone: 914-368-3160

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.