Comparison of low-dose rosuvastatin with ezetimibe versus high-dose rosuvastatin for coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of a low-dose combination of rosuvastatin and ezetimibe against high-dose rosuvastatin monotherapy in patients with minimal to intermediate coronary artery disease who have not undergone percutaneous coronary intervention. The study will assess whether the combination therapy is non-inferior in reducing major cardiovascular events compared to the high-dose treatment. It addresses the potential for fewer adverse effects associated with the combination therapy, particularly in East Asian populations. Participants will be monitored for key cardiovascular outcomes over the course of the trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male and female adjusts (19 or older)
2. Patients with suspected stable angina pectoris without coronary artery interventions, who showed a minimal to intermediate coronary artery diseases (a stenosis of 10 to 70% diameter as per QCA) in at least one natural coronary artery in coronary artery angiography or coronary artery CT.
3. Patients who gave their informed consent themselves in writing.
4. Patients who were treated with statin or lipid-lowering agents may participate in the study by changing the existing medicines.

Exclusion Criteria:

1. Patients with an intermediate (\>30%) lesion on the left main coronary artery.
2. Patients diagnosed with acute coronary artery diseases (STEMI, NSTEMI, Unstable angina)
3. Patients who received percutaneous coronary intervention
4. Patients who have been diagnosed with stroke, transitory ischemic attack, and peripheral artery diseases.
5. Patients diagnosed with variant myocardial infarction
6. Patients with severe liver diseases or lung diseases and/or malignant tumor with life expectancy of less than 3 years
7. Patients with severe valvular heart disease
8. Patients who are hypersensitive or prohibited from using the active substance (Ezetimibe or Rosuvastatin) of the study medicines
9. Patients with cardiogenic shock
10. Pregnant women or women who are planning to get pregnant
11. Patients who are receiving hemodialysis or peritoneal dialysis or received renal transplantation due to end-stage renal failure
12. Patients who participated in other clinical studies within the past three months (except for non-interventional observation studies)

Where it's running

• St. Vincent's Hospital
  Suwon, Gyeonggi-do, South Korea Recruiting

Study contacts

• Principal investigator: Sung-ho Her, MD.PhD — St Vincent's Hospital
• Study coordinator: Sung-ho Her, MD.PhD
• Email: hhhsungho@naver.com
• Phone: 821077310052

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Asprosin and miRNA Profiles in Young Women with Metabolic Syndrome

  This study tests whether certain blood biomarkers, including asprosin and six microRNAs, differ between young women with metabolic syndrome and healthy peers.

  Recruiting University of Applied Sciences in Nowy Targ · Nowy Targ, Lesser Poland Voivodeship · NCT07917364

• μFR-guided Drug-Coated Balloon Angioplasty vs Angiography-guided Angioplasty in Coronary Artery Disease

  This trial tests whether using computational μFR guidance during drug-coated balloon angioplasty is better than standard angiography guidance for people with de novo coronary artery lesions.

  Recruiting Centro Cardiologico Monzino · Cosenza, CS and 3 other locations · NCT07917234

• Gastric Ultrasound Before CABG to See if Heart Function Changes Stomach Contents

  This study checks whether people with weaker heart function before elective CABG have different stomach contents seen on ultrasound.

  Recruiting Adiyaman University · Adıyaman · NCT07898215

• Can preoperative photon-counting CT help predict heart recovery after bypass surgery?

  This observational study tests whether a preoperative photon-counting CT can help predict heart function 3 months after coronary bypass surgery in adults with coronary artery disease.

  Recruiting Chinese PLA General Hospital · Beijing · NCT07883499

• Real-World Drug-Coated Balloon Angioplasty in Coronary Artery Disease

  This registry tests how drug-coated balloons perform in everyday clinical practice for adults with coronary artery disease undergoing PCI.

  Recruiting at 5 sites Hospital Arnau de Vilanova · Mexico City, Mexico City and 4 other locations · NCT07875088

• Predicting vasopressor needs after anesthesia in elective on-pump CABG using dynamic arterial elastance

  This study tests whether EaDyn measured after induction can help predict which patients will need vasopressors during elective on-pump CABG.

  Recruiting University of Gaziantep · Gaziantep · NCT07871201

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.