Comparing wound infection risk after open versus laparoscopic gallbladder removal
Official title: Comparison of Frequency of Wound Infection Between Open and Laparoscopic Cholecystectomy
Run by Lady Reading Hospital, Pakistan · NCT07103707 · Data updated 2026-11-12
This will see if open or laparoscopic gallbladder removal causes more wound infections in adults 18–65 with symptomatic gallstones.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 122 (estimated) |
| Sponsor | Lady Reading Hospital, Pakistan Government |
| Locations | 1 site (Peshawar, Khyber Pakhtunkhwa) |
| Status | Recruiting |
| Started | August 2025 |
| Main results expected | August 2026 |
| Study ends | August 2026 |
| Registry record updated | August 5, 2025 |
| Trial ID | NCT07103707 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–65 with symptomatic cholelithiasis who are ASA I–II and planned for open or laparoscopic cholecystectomy, and who do not have diabetes or other listed exclusion conditions, are ideal candidates.
✕Probably not a fit
Patients with diabetes, immunocompromised states, acute cholecystitis, empyema, gallbladder perforation, choledocholithiasis, portal hypertension, abnormal clotting tests, or pregnancy are excluded and would not be expected to benefit from joining this comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults aged 18–65 with symptomatic cholelithiasis who are ASA I–II and scheduled for cholecystectomy will undergo either open or laparoscopic surgery and have their incision sites monitored for infection. Wound symptoms such as redness, pain, and cloudy drainage will be recorded and participants will return for an outpatient follow-up at one week. Patients with diabetes, immunocompromise, acute cholecystitis, gallbladder perforation, choledocholithiasis, portal hypertension, abnormal clotting, or pregnancy are excluded. The comparison is conducted at a single center (Lady Reading Hospital/associated site in Peshawar) to determine differences in postoperative wound infection frequency.
Why it matters
Potential benefit: If successful, the results could help surgeons choose the approach with lower wound infection risk and reduce postoperative complications and recovery time.
How similar studies have gone: Previous research generally shows lower wound infection rates after laparoscopic compared with open cholecystectomy, so this study repeats that comparison in a local patient population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Both genders * Patients aged 18 to 65 years * Symptomatic cholelithiasis as per operational definition * Undergoing cholecystectomy (open/laparoscopic) * ASA score I/II (Annexure-II) Exclusion Criteria: * ● H/o diabetes mellitus * H/o immunocompromised state (e.g. HIV, steroid use) * H/o acute cholecystitis * H/o empyema gallbladder * H/o gallbladder perforation ● H/o choledocholithiasis * H/o portal hypertension * H/o abnormal blood clotting profiles (PTT \>15 seconds, APTT \>20 seconds) * H/o pregnancy on HCG
Where it's running
-
Moeez u din khan
Peshawar, Khyber Pakhtunkhwa, Pakistan Recruiting
Study contacts
- Principal investigator: Ahmad faraz, AP GS(FCPS) — Lady reading hospital peshawar
- Study coordinator: Moeez u din khan, PGR GS
- Email: moeezk442@gmail.com
- Phone: +923489548857
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Postpartum Furosemide for Better Blood Pressure After Severe Preeclampsia
This trial tests whether adding a 5-day course of oral furosemide after delivery helps more women keep their blood pressure under control compared with placebo.
-
Intravenous labetalol versus lignocaine to reduce heart rate and blood pressure spikes during intubation for laparoscopic gallbladder removal
This test will try a single IV dose of labetalol or lignocaine given before intubation to see which better prevents sudden heart rate and blood pressure rises in adults having elective laparoscopic gallbladder surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.