Comparing warm and conventional lignocaine for dental anesthesia
Official title: Comparative Evaluation of Anesthetic Efficacy of Warm and Conventional 2% Lignocaine for the Success of Inferior Alveolar Nerve Block (IANB) in Mandibular Permanent Molars: A Randomized Controlled Clinical Trial
Run by Armed Forces Institute of Dentistry, Pakistan · NCT06806202 · Data updated 2026-11-12
This study tests if using warm lignocaine instead of room temperature lignocaine makes dental anesthesia more effective for patients getting root canal treatment on their lower back teeth.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Armed Forces Institute of Dentistry, Pakistan Academic / other |
| Locations | 1 site (Rawalpindi, Punjab Province) |
| Status | Recruiting |
| Started | December 15, 2024 |
| Main results expected | March 15, 2025 |
| Study ends | March 15, 2025 |
| Registry record updated | February 3, 2025 |
| Trial ID | NCT06806202 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy adults aged 18-50 with carious mandibular molars and acutely inflamed pulp.
✕Probably not a fit
Patients with non-vital teeth, those on preoperative medications, or individuals who are pregnant or lactating may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of warm versus conventional 2% lignocaine for inferior alveolar nerve block in patients undergoing root canal treatment for mandibular molars. A total of 200 eligible patients will be randomly assigned to receive either room temperature or pre-warmed lignocaine, with the aim of assessing success rates and onset times of anesthesia. The study will be conducted at the Armed Forces Institute of Dentistry, ensuring informed consent and ethical oversight throughout the process.
Why it matters
Potential benefit: If successful, this study could improve pain management during dental procedures, leading to better patient experiences and outcomes.
How similar studies have gone: While the specific approach of using pre-warmed lignocaine is less common, similar studies have indicated that temperature can influence anesthetic efficacy, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Permanent teeth with acutely inflamed pulp without swelling or draining sinus. * Patient who have carious mandibular molars. * Patients of either gender aged between 18-50 years old. * Systemically healthy patients. * Patients who agree to attend for recall appointments and provide a written consent Exclusion Criteria: * Patients on preoperative analgesics and antibiotics. * Teeth with calcified canals and previously treated teeth. * Pregnant and lactating mothers. * Patients who are immunocompromised, anxious and mentally handicapped. * Patients who are allergic to lignocaine. * Non-vital or necrosed teeth.
Where it's running
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Armed Forces Institute Of Dentistry
Rawalpindi, Punjab Province, Pakistan Recruiting
Study contacts
- Principal investigator: Kanza Ali Zafar, BDS — Afid
- Study coordinator: Maha Ali Mirza, BDS
- Email: mahaalimirza5@gmail.com
- Phone: 00923337808809
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.