Comparing Vonoprazan and Pantoprazole for Treating GERD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical study evaluates the efficacy of vonoprazan compared to pantoprazole in patients diagnosed with gastroesophageal reflux disease (GERD). The study focuses on patients aged 17 to 60 years who exhibit significant GERD symptoms, as measured by the Gastroesophageal Reflux Disease Questionnaire. Participants will receive either vonoprazan 20 mg or pantoprazole 40 mg for a duration of 8 weeks, with the primary goal of improving their quality of life by alleviating symptoms. The study aims to provide insights into the effectiveness of these two medications in managing GERD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 17-60 years.
* Both genders.
* Patients with a score ≥ 8 on the Gastroesophageal Reflux Disease Questionnaire (Gerd Q) are defined as having GERD and will enroll in this study and it will be done at baseline and after 8 weeks.

Exclusion Criteria:

* Subjects with history of gastrointestinal disease, gastroduodenal surgery, inflammatory bowel disease and Barrett's esophagus.
* Subjects with an earlier or current history of Zollinger-Ellison syndrome, or other gastric acid hypersecretion disorders (gastric or duodenal ulcer).
* Subjects with history of total/subtotal gastrectomy and esophageal achalasia.
* Subjects with Corona virus disease (COVID19).
* Subjects with major cardiological, respiratory, endocrine metabolic disease and neuro-psychological disease.
* Pregnancy or lactation.
* Subjects with total bilirubin level ≥ 1.2 mg/dl and ALT level \> 100 IU/l.
* Subjects with renal impairment (Crcl less than 30 ml/min).
* Patients receiving atazanavir sulphate, nelfinavir and rilpivirine hydrochloride due to potential drug interactions.

Where it's running

• Theodore Billiharz Institute for Researchs
  Giza, Egypt Recruiting

Study contacts

• Principal investigator: Aya Hany Abdel Aziz — Master degree student at faculty of pharmacy - Tanta university
• Study coordinator: Aya Hany Abdel Aziz, Bachelor
• Email: PG_172956@pharm.tanta.edu.eg
• Phone: +201144818823

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.