Comparing ventilator hyperinflation and vibrocompression for lung health in patients on mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effects of two bronchial hygiene techniques, ventilator hyperinflation and vibrocompression, on lung compliance in mechanically ventilated patients. It addresses the complications associated with mechanical ventilation, such as impaired mucociliary transport and increased risk of ventilator-associated pneumonia. The study will involve 81 patients aged 35 to 55 who have been mechanically ventilated for more than 48 hours but less than 7 days. Participants will be monitored for changes in lung compliance as a measure of the effectiveness of the interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Eighty-one mechanically ventilated patients more than 48 hours up to 7 days
* Their ages range from 35 to 55 years old.
* Medical stability (mean arterial pressure \> 60 \< 110, systolic blood pressure \> 80, diastolic blood pressure \> 60, fraction of inspired oxygen \< 60, positive end expiratory pressure (PEEP) \<10)

Exclusion Criteria:

Patients will be excluded if they have the following conditions or diseases:

* Unstable hemodynamics
* Fraction of inspired oxygen (FiO2) ≥ 0.6
* PEEP ≥ 10 cmH2O
* undrained pneumothorax and hemothorax or subcutaneous emphysema
* Pulmonary pathology (e.g., acute respiratory distress syndrome, exacerbation of chronic obstructive pulmonary disease, and acute pulmonary edema)
* Unstable neurological problems (raised intracranial pressure).
* Lung Cancer
* Recent/unhealed rib fracture
* Any disease obstructs our study.

Where it's running

• Kasr AL Ainy
  Cairo, Egypt Recruiting

Study contacts

• Principal investigator: Nadia H Mohamed, MSc — Cairo University
• Study coordinator: Nadia H Mohamed, MSc
• Email: nadia93hassan@gmail.com
• Phone: +201148709641/+201220058803

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.