Comparing ventilator hyperinflation and vibrocompression for lung health in patients on mechanical ventilation
Effects of Ventilator Hyperinflation Versus Vibrocompression on Lung Compliance in Mechanically Ventilated Patients
NA · Cairo University · NCT06791798
This study is testing whether two different lung treatments, ventilator hyperinflation and vibrocompression, can help improve lung health in patients who have been on a ventilator for a few days.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 81 (estimated) |
| Ages | 35 Years to 55 Years |
| Sex | All |
| Sponsor | Cairo University (other) |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06791798 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effects of two bronchial hygiene techniques, ventilator hyperinflation and vibrocompression, on lung compliance in mechanically ventilated patients. It addresses the complications associated with mechanical ventilation, such as impaired mucociliary transport and increased risk of ventilator-associated pneumonia. The study will involve 81 patients aged 35 to 55 who have been mechanically ventilated for more than 48 hours but less than 7 days. Participants will be monitored for changes in lung compliance as a measure of the effectiveness of the interventions.
Who should consider this trial
Good fit: Ideal candidates are mechanically ventilated patients aged 35 to 55 who have been on ventilation for more than 48 hours and are medically stable.
Not a fit: Patients with unstable hemodynamics, severe pulmonary conditions, or other significant health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve lung function and reduce complications in mechanically ventilated patients.
How similar studies have performed: While similar approaches have been used, this specific comparison of ventilator hyperinflation and vibrocompression is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Eighty-one mechanically ventilated patients more than 48 hours up to 7 days * Their ages range from 35 to 55 years old. * Medical stability (mean arterial pressure \> 60 \< 110, systolic blood pressure \> 80, diastolic blood pressure \> 60, fraction of inspired oxygen \< 60, positive end expiratory pressure (PEEP) \<10) Exclusion Criteria: Patients will be excluded if they have the following conditions or diseases: * Unstable hemodynamics * Fraction of inspired oxygen (FiO2) ≥ 0.6 * PEEP ≥ 10 cmH2O * undrained pneumothorax and hemothorax or subcutaneous emphysema * Pulmonary pathology (e.g., acute respiratory distress syndrome, exacerbation of chronic obstructive pulmonary disease, and acute pulmonary edema) * Unstable neurological problems (raised intracranial pressure). * Lung Cancer * Recent/unhealed rib fracture * Any disease obstructs our study.
Where this trial is running
Cairo
- Kasr AL Ainy — Cairo, Egypt (RECRUITING)
Study contacts
- Principal investigator: Nadia H Mohamed, MSc — Cairo University
- Study coordinator: Nadia H Mohamed, MSc
- Email: nadia93hassan@gmail.com
- Phone: +201148709641/+201220058803
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Mechanically Ventilated Patients, Lung Compliance, Airway Clearance Impairment