Comparing vasopressors for treating septic shock
Norepinephrine Equivalent Dose of Vasopressin, Phenylephrine and Epinephrine in Septic Shock Patients: A Prospective Study
This study is testing if adding different medications to norepinephrine can help patients with septic shock on mechanical ventilation feel better and improve their treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Sanjay Gandhi Postgraduate Institute of Medical Sciences Government |
| Locations | 1 site (Lucknow, Uttar Pradesh) |
| Trial ID | NCT06499467 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with septic shock who are on mechanical ventilation and receiving norepinephrine. It aims to evaluate the effectiveness of adding other vasopressors by developing a standardized formula called Norepinephrine Equivalence (NEE) to quantify the potency of various vasopressors. The study will include patients who have been on a stable dose of norepinephrine for a specified period and will assess their response to additional vasopressor treatment. The goal is to improve management strategies for septic shock in intensive care settings.
Who should consider this trial
Good fit: Ideal candidates are adult patients on mechanical ventilation with septic shock who are receiving a stable dose of norepinephrine.
Not a fit: Patients with other forms of shock or those experiencing arrhythmias or hypovolemia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatment protocols for patients suffering from septic shock.
How similar studies have performed: While the approach of quantifying vasopressor potency is innovative, similar studies have not been widely reported, making this a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adult patients on mechanical ventilation in septic shock receiving norepinephrine in whom the treating clinical team plan to add another vasopressor, will be considered for inclusion if they meet these two condition (1) Patient is on Norepinephrine infusion at least 0.1 mcg/kg/min for the last 6 hours; and (2) There has been no dose alteration in the infusion of norepinephrine for the last 2 hours Exclusion Criteria: * There are concurrently other forms of shock like cardiogenic, obstructive, anaphylactic or hypovolemic. * The patient has arrhythmias during the current course of illness. * The patient has asynchrony on mechanical ventilator despite airway clearance with suctioning and adequate sedation at the time of study measurement. * The patient is hypovolemic with ongoing fluid resuscitation in the form of fluid boluses, blood or blood product transfusions at the time of study measurement. * The patient receives diuretic boluses or undergoes hemodialysis sessions at the time of study measurement. * Pregnancy * Patient who didn't consent for study or withdrew the consent at any point of the study.
Where this trial is running
Lucknow, Uttar Pradesh
- Sanjay Gandhi Postgraduate Institute of Medical Sciences — Lucknow, Uttar Pradesh, India (Recruiting)
Study contacts
- Principal investigator: Mohan Gurjar, MD, PDCC — Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)
- Study coordinator: Mohan Gurjar, MD, PDCC
- Email: m.gurjar@rediffmail.com
- Phone: +91-522-249-5403
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.