Comparing vancomycin dosing methods for serious MRSA infections
Official title: Vancomycin Dosing for Serious MRSA Infections: A Non-inferiority Randomized Trial of Trough Level Versus AUC/MIC
Run by Queen's University · NCT04793152 · Data updated 2026-11-12
This study tests if a simpler way of giving vancomycin can work just as well as a more complicated method for adults with serious MRSA infections.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 700 (estimated) |
| Sponsor | Queen's University Academic / other |
| Locations | 4 sites (Hamilton, Ontario and 3 other locations) |
| Status | Recruiting |
| Started | March 20, 2023 |
| Main results expected | July 2029 |
| Study ends | October 2029 |
| Registry record updated | January 23, 2026 |
| Trial ID | NCT04793152 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with serious MRSA infections who have not received vancomycin for more than four days.
✕Probably not a fit
Patients with a vancomycin MIC of 2ug/mL or higher, or those who are palliative or critically ill, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness of two different dosing strategies for intravenous vancomycin in treating serious methicillin-resistant Staphylococcus aureus (MRSA) infections. It compares the traditional trough level approach with a newer method that targets the area under the curve over 24 hours relative to the minimum inhibitory concentration (AUC/MIC). The study aims to determine if the simpler trough level dosing can be as effective as the more complex AUC/MIC method without compromising patient outcomes. Eligible participants include adults with serious MRSA infections who have not been on vancomycin for more than four days.
Why it matters
Potential benefit: If successful, this study could simplify vancomycin dosing for MRSA infections, making treatment more accessible and efficient for patients.
How similar studies have gone: Other studies have explored vancomycin dosing strategies, but this specific comparison of trough versus AUC/MIC is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients with serious MRSA infections based on culture results including bacteremia, pneumonia, pleural space infection, central nervous system infection, bone infection, septic arthritis, prosthetic joint infection, and deep abscess * Enrolment within 4 days from date of MRSA culture collection * Patient either currently not on vancomycin or has received vancomycin for 4 days or less Exclusion Criteria: * Vancomycin minimum inhibitory concentration (MIC) ≥2ug/mL * Patient is palliative or expected to die in the next 48 hours, or requires critical care resources but will not receive it due to advanced care directives * History of type 1 hypersensitivity reaction to vancomycin * Patients on intermittent hemodialysis or peritoneal dialysis
Where it's running
-
Hamilton Health Sciences
Hamilton, Ontario, Canada Recruiting -
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada Recruiting -
Kingston Health Sciences Centre
Kingston, Ontario, Canada Recruiting -
McGill University Health Centre
Montreal, Quebec, Canada Recruiting
Study contacts
- Principal investigator: Anthony D Bai, MD — Queen's University
- Study coordinator: Anthony D Bai, MD
- Email: tony.bai@queensu.ca
- Phone: 613-533-6000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.