Comparing ultrasound elastography to respiratory function tests
Comparison of Shear-wave Elastography to State-of-the-art Respiratory Function Testing to Measure the Range of Forces Generated by the Diaphragm Muscle
This study is testing if a new ultrasound method can better measure how well the diaphragm works compared to standard breathing tests in healthy adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT04959526 on ClinicalTrials.gov |
What this trial studies
This study evaluates the relationship between transdiaphragmatic pressure and diaphragm shear-wave elastography during advanced respiratory muscle testing. It involves healthy adult volunteers undergoing various respiratory tests, including maximal inspiratory and expiratory pressures, as well as phrenic nerve stimulation. The goal is to determine how effectively shear-wave elastography can assess diaphragm function compared to traditional respiratory function tests.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adult males and females without any known pulmonary pathology.
Not a fit: Patients with existing respiratory conditions such as COPD or asthma requiring routine treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the assessment of diaphragm function, leading to better management of respiratory conditions.
How similar studies have performed: While the use of shear-wave elastography is gaining interest, this specific comparison with respiratory function testing is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Adult male and female healthy volunteers. Exclusion Criteria: * Volunteers who are pregnant. * Volunteers with known pulmonary pathology (COPD, asthma requiring routine treatment).
Where this trial is running
Rochester, Minnesota
- Mayo Clinic in Rochester — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Carlos Matilla, MD, PhD — Mayo Clinic
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.