Comparing two volumes of Articaine for dental extractions

Comparing the Effectiveness of Buccal Infiltration of Different Volumes of Articaine for Extraction of Mandibular Posterior Teeth- A Randomized Clinical Trial.

Not applicable Interventional Qassim University · NCT06630819

This study is testing whether using a smaller or larger amount of a local anesthetic called Articaine helps people feel less pain during the extraction of their back teeth.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment114 (estimated)
Ages18 Years and up
SexAll
SponsorQassim University Academic / other
Locations2 sites (Buraidah, Al Qassim and 1 other locations)
Trial IDNCT06630819 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of two different volumes of buccal infiltration of Articaine, a local anesthetic, for the extraction of mandibular posterior teeth. Participants will receive either 1.8 ml or 3.6 ml of 4% Articaine to determine which volume provides better anesthesia. The study aims to address complications associated with the inferior alveolar nerve block technique by utilizing a safer and less painful local infiltration method. The research will involve healthy patients aged 18 and older who require dental extractions.

Who should consider this trial

Good fit: Ideal candidates are healthy adults aged 18 and older requiring extraction of mandibular posterior teeth.

Not a fit: Patients with acute infections at the extraction site or those requiring surgical extractions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved pain management during dental extractions, enhancing patient comfort and outcomes.

How similar studies have performed: Previous studies have shown that local infiltration techniques can be effective, but this specific comparison of Articaine volumes is novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* All healthy patients (ASA I) or patients with mild systemic disease with no functional limitations (ASA II)
* Patients aged ≥ 18 years of age.
* Patients requiring extraction of mandibular posterior teeth including grossly decayed tooth, grade I mobile tooth, root stumps and indicated for therapeutic reasons.
* Patients not allergic to the drugs or anesthetic agents used in the surgery.

Exclusion Criteria:

* Acute infection at the extraction site.
* Patients indicated for surgical extraction of teeth.
* Patients already taking medications affecting pain assessment.
* Pregnant patients.

Where this trial is running

Buraidah, Al Qassim and 1 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Buccal InfiltrationArticaineAnesthesiaBuccal infiltration
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.