Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Comparing two volumes of Articaine for dental extractions

Official title: Comparing the Effectiveness of Buccal Infiltration of Different Volumes of Articaine for Extraction of Mandibular Posterior Teeth- A Randomized Clinical Trial.

Run by Qassim University · NCT06630819 · Data updated 2026-11-12

This study is testing whether using a smaller or larger amount of a local anesthetic called Articaine helps people feel less pain during the extraction of their back teeth.

More General Anesthesia trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment114 (estimated)
SponsorQassim University
Academic / other
Locations2 sites (Buraidah, Al Qassim and 1 other locations)
StatusRecruiting
StartedNovember 24, 2024
Main results expectedMay 2, 2026
Study endsMay 2, 2026
Registry record updatedMay 29, 2025
Trial IDNCT06630819 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are healthy adults aged 18 and older requiring extraction of mandibular posterior teeth.

Probably not a fit

Patients with acute infections at the extraction site or those requiring surgical extractions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of two different volumes of buccal infiltration of Articaine, a local anesthetic, for the extraction of mandibular posterior teeth. Participants will receive either 1.8 ml or 3.6 ml of 4% Articaine to determine which volume provides better anesthesia. The study aims to address complications associated with the inferior alveolar nerve block technique by utilizing a safer and less painful local infiltration method. The research will involve healthy patients aged 18 and older who require dental extractions.

Why it matters

Potential benefit: If successful, this study could lead to improved pain management during dental extractions, enhancing patient comfort and outcomes.

How similar studies have gone: Previous studies have shown that local infiltration techniques can be effective, but this specific comparison of Articaine volumes is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* All healthy patients (ASA I) or patients with mild systemic disease with no functional limitations (ASA II)
* Patients aged ≥ 18 years of age.
* Patients requiring extraction of mandibular posterior teeth including grossly decayed tooth, grade I mobile tooth, root stumps and indicated for therapeutic reasons.
* Patients not allergic to the drugs or anesthetic agents used in the surgery.

Exclusion Criteria:

* Acute infection at the extraction site.
* Patients indicated for surgical extraction of teeth.
* Patients already taking medications affecting pain assessment.
* Pregnant patients.

Where it's running

  • College of Dentistry, Qassim University
    Buraidah, Saudi Arabia
    Recruiting
  • Qassim University
    Buraidah, Al Qassim, Saudi Arabia
    Not yet recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.