Comparing two versus three cycles of chemotherapy for advanced nasopharyngeal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multi-center phase III clinical trial aims to determine if two cycles of induction chemotherapy combined with concurrent chemoradiotherapy is as effective as three cycles in treating patients with locally advanced nasopharyngeal carcinoma. The study will enroll patients aged 18-65 with pathologically confirmed non-keratinizing nasopharyngeal carcinoma, specifically those at stage T3-4N0-1 without distant metastasis. Participants will be randomly assigned to receive either two or three cycles of chemotherapy before concurrent treatment. The goal is to assess the efficacy and safety of the shorter treatment regimen.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 18-65 years old;
2. Pathologically confirmed non-keratinizing nasopharyngeal carcinoma;
3. Stage T3-4N0-1 (according to the UICC/AJCC 8th);
4. No distant metastasis;
5. Have not received anti-cancer treatment in the past;
6. ECOG (Eastern Cooperative Oncology Group of the United States): 0-1;
7. Adequate hematologic, hepatic and renal function.

Exclusion Criteria:

1. The purpose of treatment is palliative;
2. Diagnosed with other malignant tumors at the same time;
3. Malignant tumor history;
4. Pregnancy or breastfeeding, or expect to become pregnant during the clinical trial period;
5. Combined serious illness.

Where it's running

• First Affiliated Hospital, Sun Yat-Sen University
  Guangzhou, Other (Non U.s.), China Recruiting

Study contacts

• Study coordinator: Cheng-Tao Wang
• Email: wangcht5@mail.sysu.edu.cn
• Phone: +862087755766

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Comparing two treatment approaches for advanced nasopharyngeal cancer

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  Recruiting Phase 3 First Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT05062005

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.