Comparing two ventilation methods during laryngotracheal surgery
Official title: Comparison of Flow-Controlled Ventilation With EVONE Tritube and High Frequency Jet Ventilation in Patients Undergoing Laryngotracheal Surgery
Run by University Hospital, Geneva · NCT06063798 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing which breathing method, Flow Controlled Ventilation or High-Frequency Jet Ventilation, works better for protecting the lungs during laryngotracheal surgery in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University Hospital, Geneva Academic / other |
| Locations | 1 site (Geneva) |
| Trial ID | NCT06063798 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult patients scheduled for elective laryngotracheal surgery under general anesthesia.
✕Probably not a fit
Patients with severe heart or respiratory diseases, obesity, or those requiring tracheotomy will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the respiratory effects of two ventilation techniques, Flow Controlled Ventilation (FCV) and High-Frequency Jet Ventilation (HFJV), in patients undergoing laryngotracheal surgery under general anesthesia. The study is randomized and controlled, enrolling 50 adult patients who will be assigned to either the FCV or HFJV group. Measurements of lung function and respiratory mechanics will be taken before and after surgery to assess the effectiveness of each ventilation method. The goal is to determine which technique provides better lung protection and ventilation efficiency during the procedure.
Why it matters
Potential benefit: If successful, this study could lead to improved ventilation strategies that enhance lung protection during laryngotracheal surgeries.
How similar studies have gone: While the approach of using FCV is relatively novel, previous studies have indicated potential benefits of advanced ventilation techniques in similar surgical contexts.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Informed Consent signed by the subject * General anesthesia for laryngotracheal surgery * Adult patients, female and male, over 18 years of age * Elective surgery Exclusion Criteria: * Documented severe heart conditions (New York Heart Association Class 4, severe pulmonary hypertension) * Documented severe respiratory disease (uncontrolled asthma, severe pulmonary fibrosis, chronic obstructive pulmonary disease GOLD 4) * Documented severe Neurological diseases (Acute ischemic and hemorrhagic stroke within the preceding 3 months, uncontrolled seizures) * Surgery that requires tracheotomy * Obesity (Body Mass Index ≥ 30 kg/m2) * Inability to follow the procedures of the study (mental condition or language barrier e.g. incomprehension of French language) * Previous enrolment into the current study or other study that involves unknown medication in the past 12 months * Allergy or contraindication to Propofol and/or Remifentanil and/or Rocuronium
Where it's running
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Geneva University Hospitals
Geneva, Switzerland Recruiting
Study contacts
- Principal investigator: Gergely Albu, MD, PhD — University Hospital, Geneva
- Study coordinator: Gergely Albu, MD, PhD
- Email: gergely.albu@hcuge.ch
- Phone: 0041795532052
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.