Comparing two types of wound dressings for tooth extraction sites
Comparison of Porcine Collagen Membrane and Bovine Collagen Wound Dressing in Human Extraction Sites With DFDBA Graft: A Randomized Controlled Trial
This study is testing whether using pig or cow collagen dressings after tooth extractions helps improve healing for adults needing dental grafts.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 19 Years to 65 Years |
| Sex | All |
| Sponsor | University of Nebraska Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Lincoln, Nebraska) |
| Trial ID | NCT05802602 on ClinicalTrials.gov |
What this trial studies
This study aims to compare the effectiveness of porcine collagen membranes versus bovine collagen wound dressings in human tooth extraction sites. It will involve a double-blind randomized controlled trial with 24 nonsmoking adults aged 18-65 who require premolar or anterior tooth extractions and graft procedures. Participants will undergo baseline data collection, including gingival crevicular fluid sampling and Cone Beam Computed Tomography imaging, before receiving one of the two wound dressings after their tooth extraction. The outcomes measured will include changes in soft tissue thickness and bone density.
Who should consider this trial
Good fit: Ideal candidates are nonsmoking adults aged 18-65 in good general health requiring premolar or anterior tooth extraction and graft procedures.
Not a fit: Patients with a history of radiation therapy, bisphosphonate use, or systemic conditions affecting bone healing may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve healing outcomes for patients undergoing tooth extractions and graft procedures.
How similar studies have performed: Other studies have shown success with similar approaches in wound healing, but this specific comparison is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Non-smoking * Aged 19-65 * Requiring premolar or anterior tooth extraction and graft procedures * Good general health * Willing to provide informed consent. Exclusion Criteria: * History of radiation therapy or bisphosphonate use * Pregnancy or breastfeeding * Systemic conditions that affect bone healing * Contraindications to dental implants * Inability to attend follow-up visits.
Where this trial is running
Lincoln, Nebraska
- University of Nebraska Medical Center, College of Dentistry — Lincoln, Nebraska, United States (Recruiting)
Study contacts
- Principal investigator: Amy C Killeen, DDS, MS — University of Nebraska
- Study coordinator: Amy C Killeen, DDS, MS
- Email: akilleen@unmc.edu
- Phone: 402-472-7848
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.