Clinical trial Recruiting at 1 site Interventional Ages 18 to 45

Comparing two types of platelet-rich fibrin for dental implants

Official title: Clinical and Radiographic Evaluation of Xenograft With Albumin Platelet-Rich Fibrin or Leucocyte- Platelet-Rich Fibrin on Immediate Implant Placement in Mandibular Molar Extraction Sites: Randomized Clinical Trial.

Run by Kafrelsheikh University · NCT06863051 · Data updated 2026-11-12

This study is testing which of two types of platelet-rich fibrin helps dental implants work better for patients getting immediate implants after losing their back teeth.

More Immediate Implant Placement trials

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexAll
Enrollment20 (estimated)
SponsorKafrelsheikh University
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Kafr ash Shaykh, Kafrelsheikh)
StatusRecruiting
StartedAugust 20, 2025
Main results expectedFebruary 10, 2026
Study endsFebruary 10, 2027
Registry record updatedAugust 1, 2025
Trial IDNCT06863051 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients aged 18-45 with non-restorable mandibular molars and intact buccal and lingual walls.

Probably not a fit

Patients with systemic disorders, acute infections, or those undergoing chemotherapy or radiotherapy may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the effectiveness of two different types of platelet-rich fibrin (Alb-PRF and L-PRF) when used in conjunction with xenograft for immediate dental implant placement. It will evaluate various parameters such as peri-implant vertical defect depth, crestal bone level, bucco-lingual bone width, and keratinized tissue width. The study will involve patients with non-restorable mandibular molars who meet specific inclusion criteria and will assess the outcomes of the implants placed using these two different fibrin preparations.

Why it matters

Potential benefit: If successful, this study could improve the outcomes of immediate dental implant placements, leading to better bone integration and tissue health.

How similar studies have gone: While there have been studies on platelet-rich fibrin in dental procedures, the specific comparison of Alb-PRF and L-PRF in immediate implant placement is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
1. Inclusion criteria

   * The presence of non-restorable mandibular molar.
   * Patient 18-45 years old
   * Intact buccal and lingual walls
   * Good oral hygiene.
   * Prescence of sufficient restorative space.
   * Jumping gap more than 2 mm.
2. Exclusion criteria

   * Proximity of anatomical structures
   * Acute localized infection (suppuration at the surgical field)
   * Patients on chemotherapy or radiotherapy.
   * Patients who have systemic disorders (diseases) {diabetes mellitus, autoimmune disease, …etc},
   * Pregnant patients.
   * Smoking and Alcohols.
   * Presence of periapical pathology affecting the neighboring teeth.

Where it's running

  • Kafrelsheikh University, Faculty of Dentistry
    Kafr ash Shaykh, Kafrelsheikh, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.