Comparing two types of platelet-rich fibrin for dental implants
Official title: Clinical and Radiographic Evaluation of Xenograft With Albumin Platelet-Rich Fibrin or Leucocyte- Platelet-Rich Fibrin on Immediate Implant Placement in Mandibular Molar Extraction Sites: Randomized Clinical Trial.
Run by Kafrelsheikh University · NCT06863051 · Data updated 2026-11-12
This study is testing which of two types of platelet-rich fibrin helps dental implants work better for patients getting immediate implants after losing their back teeth.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Kafrelsheikh University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Kafr ash Shaykh, Kafrelsheikh) |
| Status | Recruiting |
| Started | August 20, 2025 |
| Main results expected | February 10, 2026 |
| Study ends | February 10, 2027 |
| Registry record updated | August 1, 2025 |
| Trial ID | NCT06863051 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients aged 18-45 with non-restorable mandibular molars and intact buccal and lingual walls.
✕Probably not a fit
Patients with systemic disorders, acute infections, or those undergoing chemotherapy or radiotherapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to compare the effectiveness of two different types of platelet-rich fibrin (Alb-PRF and L-PRF) when used in conjunction with xenograft for immediate dental implant placement. It will evaluate various parameters such as peri-implant vertical defect depth, crestal bone level, bucco-lingual bone width, and keratinized tissue width. The study will involve patients with non-restorable mandibular molars who meet specific inclusion criteria and will assess the outcomes of the implants placed using these two different fibrin preparations.
Why it matters
Potential benefit: If successful, this study could improve the outcomes of immediate dental implant placements, leading to better bone integration and tissue health.
How similar studies have gone: While there have been studies on platelet-rich fibrin in dental procedures, the specific comparison of Alb-PRF and L-PRF in immediate implant placement is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
1. Inclusion criteria
* The presence of non-restorable mandibular molar.
* Patient 18-45 years old
* Intact buccal and lingual walls
* Good oral hygiene.
* Prescence of sufficient restorative space.
* Jumping gap more than 2 mm.
2. Exclusion criteria
* Proximity of anatomical structures
* Acute localized infection (suppuration at the surgical field)
* Patients on chemotherapy or radiotherapy.
* Patients who have systemic disorders (diseases) {diabetes mellitus, autoimmune disease, …etc},
* Pregnant patients.
* Smoking and Alcohols.
* Presence of periapical pathology affecting the neighboring teeth.
Where it's running
-
Kafrelsheikh University, Faculty of Dentistry
Kafr ash Shaykh, Kafrelsheikh, Egypt Recruiting
Study contacts
- Study coordinator: Mostafa Mohamed Fayed, Demonstrator of Periodontology
- Email: mostafa.mohamed@den.kfs.edu.eg
- Phone: 0201004668099
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Socket-shield versus conventional immediate implant placement in the front jaw
This trial tests whether using the socket-shield technique during immediate implant placement in the upper front teeth better preserves bone and gum health than the standard method.
-
Magnesium membrane versus dual‑zone grafting for immediate implant placement in the aesthetic zone
This will test whether a magnesium membrane combined with bovine bone gives better bone and gum volume, improved esthetics, and less pain than dual‑zone grafting for adults receiving immediate implants in the upper front teeth.
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This trial will see if two different xenograft materials help preserve the labial bone plate when placing immediate implants in Type II extraction sockets in the upper front jaw.
-
Osseodensification forMol ar Septum Expansion in Immediate Molar Implants
This study tests whether osseodensification helps place immediate molar implants more stably compared with traditional drilling, in adults needing extraction and replacement teeth.
-
Comparing xenograft mixed with vitamin D to hyaluronic acid for immediate dental implants
This study tests whether using a mix of vitamin D with a type of bone graft works better than hyaluronic acid for placing immediate dental implants in the back of the jaw.
-
Evaluating Doxycycline Nanoparticles with Gelatin Sponge for Immediate Dental Implants
This study tests if using doxycycline nanoparticles with a gelatin sponge can improve the success of immediate dental implants compared to standard treatment for patients getting implants in the front of their mouth.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.