Comparing two types of platelet-rich fibrin for dental implants
Clinical and Radiographic Evaluation of Xenograft With Albumin Platelet-Rich Fibrin or Leucocyte- Platelet-Rich Fibrin on Immediate Implant Placement in Mandibular Molar Extraction Sites: Randomized Clinical Trial.
This study is testing which of two types of platelet-rich fibrin helps dental implants work better for patients getting immediate implants after losing their back teeth.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Kafrelsheikh University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Kafr ash Shaykh, Kafrelsheikh) |
| Trial ID | NCT06863051 on ClinicalTrials.gov |
What this trial studies
This study aims to compare the effectiveness of two different types of platelet-rich fibrin (Alb-PRF and L-PRF) when used in conjunction with xenograft for immediate dental implant placement. It will evaluate various parameters such as peri-implant vertical defect depth, crestal bone level, bucco-lingual bone width, and keratinized tissue width. The study will involve patients with non-restorable mandibular molars who meet specific inclusion criteria and will assess the outcomes of the implants placed using these two different fibrin preparations.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged 18-45 with non-restorable mandibular molars and intact buccal and lingual walls.
Not a fit: Patients with systemic disorders, acute infections, or those undergoing chemotherapy or radiotherapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the outcomes of immediate dental implant placements, leading to better bone integration and tissue health.
How similar studies have performed: While there have been studies on platelet-rich fibrin in dental procedures, the specific comparison of Alb-PRF and L-PRF in immediate implant placement is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
1. Inclusion criteria
* The presence of non-restorable mandibular molar.
* Patient 18-45 years old
* Intact buccal and lingual walls
* Good oral hygiene.
* Prescence of sufficient restorative space.
* Jumping gap more than 2 mm.
2. Exclusion criteria
* Proximity of anatomical structures
* Acute localized infection (suppuration at the surgical field)
* Patients on chemotherapy or radiotherapy.
* Patients who have systemic disorders (diseases) {diabetes mellitus, autoimmune disease, …etc},
* Pregnant patients.
* Smoking and Alcohols.
* Presence of periapical pathology affecting the neighboring teeth.
Where this trial is running
Kafr ash Shaykh, Kafrelsheikh
- Kafrelsheikh University, Faculty of Dentistry — Kafr ash Shaykh, Kafrelsheikh, Egypt (Recruiting)
Study contacts
- Study coordinator: Mostafa Mohamed Fayed, Demonstrator of Periodontology
- Email: mostafa.mohamed@den.kfs.edu.eg
- Phone: 0201004668099
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.