Comparing two types of phosphate injections for parenteral nutrition

Phase 1, Prospective, Single-Center, Randomized Sequence, Double-Blind, 2-Way Crossover Study Comparing Organic Phosphate (Sodium Glycerophosphate Injection) to Inorganic Phosphate (Sodium Phosphates Injection, USP)

This study is testing which of two phosphate injections is better absorbed by the body in healthy adults to help improve nutritional treatments.

Quick facts

• Phase: PHASE1
• Study type: Interventional
• Enrollment: 42 (estimated)
• Ages: 18 Years to 55 Years
• Sex: All
• Sponsor: Baxter Healthcare Corporation (industry)
• Locations: 1 site (Austin, Texas)
• Trial ID: NCT06842121 on ClinicalTrials.gov

What this trial studies

This phase 1 clinical trial is designed to compare the bioavailability of Sodium Glycerophosphate Injection (SGP) and Sodium Phosphate Injection (NaP) in healthy adult subjects. Approximately 42 participants will be randomized in a double-blind, two-way crossover format to assess how each injection is absorbed in the body. The study will take place over an 11-day residency period, during which all necessary assessments will be conducted. The focus is on understanding the pharmacokinetics of these two phosphate formulations to inform future nutritional therapies.

Who should consider this trial

Good fit: Ideal candidates are healthy males and non-pregnant, non-lactating females aged 18 to 55 with a BMI between 18.5 and 29.9.

Not a fit: Patients with existing health conditions or those outside the specified age and BMI range may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide insights into more effective phosphate supplementation for patients requiring parenteral nutrition.

How similar studies have performed: While similar studies have been conducted, this specific comparison of organic versus inorganic phosphate injections is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Healthy males or non-pregnant, non-lactating healthy females.
2. Aged 18 to 55 years, inclusive, at the time of signing informed consent.
3. Body mass index (BMI) of 18.5 to 29.9 kg/m\^2 and a minimum body weight of 57 kg as measured at screening.
4. Must be willing and able to comply with all study requirements including dietary requirements.
5. Subject must be literate, has signed a written informed consent form (ICF) and has the ability to communicate and comply with all study requirements
6. Must agree to use an adequate method of contraception.
7. Alkaline phosphatase level within standard reference range/normal limits at screening and admission.
8. Serum inorganic phosphate level within standard reference range/normal limits at screening and admission.
9. Serum parathyroid hormone (PTH) level within standard reference range/normal limits at screening.
10. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels within reference range/normal limits at screening and admission.

Exclusion Criteria:

1. Subjects who have received any investigational medicinal product (IMP) in a clinical research study within 5 half-lives or within 30 days prior to first dose, whichever is longer.
2. Subjects who are study site or Sponsor employees, or subjects who are immediate family members of study site or Sponsor employees.
3. Subjects who have previously been administered IMP in this study.
4. History of any drug or alcohol abuse in the past 2 years prior to screening.
5. Regular alcohol consumption in 6 months prior to screening.
6. A confirmed positive alcohol urine test at screening or admission.
7. Current smokers or those who have smoked within the last 12 months prior to screening. A confirmed positive urine cotinine test at screening or first admission.
8. Current users of e-cigarettes and nicotine replacement products and those who have used these products within the last 12 months prior to screening.
9. Females of childbearing potential must have a negative pregnancy test (urine pregnancy test at screening). Females who are pregnant or lactating will be excluded.
10. Have poor venous access that limits phlebotomy.
11. Clinically significant abnormal clinical chemistry or hematology as judged by the Investigator.
12. Clinically significant abnormal urinalysis as judged by the Investigator.
13. History of diabetes mellitus (types I or II).
14. Prediabetes (fasting blood sugar level of \>106 (repeat x 1 for confirmation of abnormal level).
15. Hypertriglyceridemia (fasting triglyceride level of \> 200 mg/dL) at screening.
16. Subjects who, in the Investigator's opinion, have a clinically significant abnormal 12-lead resting ECG.
17. Positive drugs of abuse test result.
18. Positive hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV Ab) or human immunodeficiency virus (HIV) antibody results.
19. Evidence of renal impairment at screening, as indicated by an eGFR \< 90mL/min/m\^2.
20. History of any active systemic or immunologic disease, including but not limited to active renal, hepatic, hematological, gastrointestinal (except appendectomies/cholecystectomy), endocrinal, pulmonary (including asthma), cardiovascular, neurologic, or neurological disease (including demyelinating diseases such as multiple sclerosis), hypertension, tuberculosis, or systemic fungal infection.
21. History of bleeding ulcer, bleeding abnormalities or coagulation abnormalities.
22. History of hypophosphatasia.
23. Serious adverse reaction or serious hypersensitivity to any drug or the formulation excipients.
24. Presence or history of clinically significant allergy requiring treatment, as judged by the Investigator. Hay fever is allowed unless it is active.
25. Significant serious active skin disease, including rash, food allergy, eczema, psoriasis, or urticaria.
26. Donation or loss of 1 pint of blood within 3 months, or donation of plasma within 7 days prior to first dose of study medication or had a transfusion of any blood product within 3 months prior to study drug administration.
27. Subjects who are taking, or have taken, any prescribed or over-the-counter drug or herbal remedies (other than up to 4 g per day acetaminophen and HRT/hormonal contraception) within the last 30 days or five half-lives (whichever is longer), before IMP administration. Exceptions may apply on a case-by-case basis, if considered not to interfere with the objectives of the study, as determined by the Investigator.
28. Subjects who have been administered a drug by depot injection within 30 days prior to the initial study drug administration or 6 half-lives of that drug, whichever is longer and at the discretion of the Investigator or who have received a recent (as determined by the Investigator) live or attenuated vaccination (with exception of a COVID-19 vaccine or flu vaccine), or exposure to communicable viral diseases such as chicken pox, varicella, and measles.
29. Failure to satisfy the Investigator of fitness to participate for any other reason.
30. Known hypersensitivity to egg, soy or peanut proteins.
31. Food allergies deemed clinically relevant by the investigator which would hinder ability to adhere to the prescribed diet.

Where this trial is running

Austin, Texas

• Austin PPD CRU — Austin, Texas, United States (RECRUITING)

Study contacts

• Study coordinator: Clinical Research Manager

Conditions: Parenteral Nutrition, organic phosphate, inorganic phosphate, sodium glycerophosphate, pharmacokinetic, intravenous, parenteral nutrition