Comparing two types of membranes for bone regeneration after tooth extraction
Official title: A Randomized Controlled Trial Comparing Titanium Reinforced d-PTFE Membrane to Collagen Membrane for Guided Bone Regeneration at Single Tooth Sites in the Premaxilla: a Clinical, CBCT and Histomorphometric Analysis
Run by University Ghent · NCT05426616 · Data updated 2026-11-12
This study tests which type of membrane works better for helping patients grow new bone after having a tooth pulled, so they can get dental implants later.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 36 (estimated) |
| Sponsor | University Ghent Academic / other |
| Locations | 3 sites (Ghent, Oost-Vlaanderen and 2 other locations) |
| Status | Recruiting |
| Started | June 1, 2022 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2028 |
| Registry record updated | July 15, 2024 |
| Trial ID | NCT05426616 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients who have had a tooth extracted at least three months prior and have a single tooth gap in the anterior maxilla with good oral hygiene.
✕Probably not a fit
Patients with systemic diseases, a history of smoking or periodontal disease, untreated caries, or those who are pregnant may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of two different membranes, a resorbable collagen membrane and a titanium reinforced d-PTFE membrane, in guided bone regeneration for patients needing dental implants after tooth extraction. Participants must have a single tooth gap in the anterior maxilla and sufficient oral hygiene. The study aims to measure changes in bone dimensions following the application of these membranes in conjunction with a combination of xenogenous and autologous bone. The goal is to determine which membrane provides better outcomes for bone volume restoration.
Why it matters
Potential benefit: If successful, this study could improve the success rate of dental implants by optimizing bone regeneration techniques.
How similar studies have gone: Previous studies have shown varying success with guided bone regeneration techniques, but this specific comparison of membrane types is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * good oral hygiene defined as full-mouth plaque score ≤ 25% (O'Leary et al. 1972) * presence of a single tooth gap in the anterior maxilla (15-25) with both neighboring teeth present * failing tooth at least 3 months earlier removed Exclusion Criteria: * systemic diseases * smoking; (history of) periodontal disease * untreated caries lesions * pregnancy (will be explicitly asked)
Where it's running
-
Universitair Ziekenhuis Gent
Ghent, Oost-Vlaanderen, Belgium Recruiting -
Centrum voor Parodontologie en Orale Implantologie
Zottegem, Oost-Vlaanderen, Belgium Recruiting -
Parodonto
Zwijnaarde, Oost-Vlaanderen, Belgium Recruiting
Study contacts
- Principal investigator: Jan Cosyn, Professor — University Ghent
- Study coordinator: Jan Cosyn, Professor
- Email: jan.cosyn@ugent.be
- Phone: 093324017
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.