Comparing two types of dextrose injections for knee osteoarthritis treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of intra-articular versus MRI-guided extra-articular dextrose injections for managing knee osteoarthritis. Participants aged 45 to 80 who meet specific criteria will receive either type of injection to determine which approach yields better outcomes. The study aims to assess the benefits of targeting MRI-positive lesion sites compared to standard intra-articular injections. By utilizing MRI for precise targeting, the researchers hope to enhance treatment efficacy for knee osteoarthritis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. . age between 45 to 80 years old;
2. . meet at least three of the six American College of Rheumatology (ACR) criteria, including age over 50 years, morning stiffness less than 30 minutes, crepitus in passive knee movements, bony tenderness, bony enlargement, and no palpable warmth;
3. . radiologic grading of 2 or 3 according to Kellgren-Lawrence criteria;
4. showing willingness to receive prolotherapy.

Exclusion Criteria:

1. . severe systemic disorders including cancer, uncontrolled diabetes mellitus, sepsis, or cardiopulmonary diseases;
2. . history of anticoagulation therapy, knee injection over the past three months;
3. . history of knee surgery or candidates for knee arthroplasty;
4. . history of drug abuse;
5. . a history of intolerance to prolotherapy;
6. . pregnancy;
7. . infectious arthritis, inflammatory joint diseases, joint dysplasia;
8. Body Mass Index (BMI) greater than 35 kg/m2;
9. . not suitable or no willing to received MRI examination of the knee.

Where it's running

• Shin Kong Wu Ho-Su Memorial Hospital
  Taipei, Taiwan Recruiting

Study contacts

• Principal investigator: Lin-Fen Hsieh — Shin Kong Wu Ho-Su Memorial Hospital
• Study coordinator: Lin-Fen Hsieh
• Email: M001026@ms.skh.org.tw
• Phone: +886-28332211

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.