Comparing two types of collagen membranes for bone regeneration

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of fixed versus non-fixed resorbable collagen membranes in promoting horizontal bone gain during Guided Bone Regeneration (GBR) procedures. Participants will receive a mixture of xenograft and allograft as a bone substitute, with one group using fixed membranes and the other using non-fixed membranes. The primary outcome will be measured at six months post-treatment, focusing on the amount of bone gained to facilitate dental implant placement. The study is designed to provide insights into which membrane type yields better results in patients with insufficient ridge width.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Men and women over 18 years old or older
2. Patients requiring Guided Bone Regeneration due to insufficient ridge width(≤5mm) to place dental implants, with sufficient vertical ridge height (≥9mm) from vital anatomical structures (the inferior alveolar nerve in the Mandible, or the sinus in the Maxilla)
3. One or more teeth missing in posterior zone (Premolars, and Molars)
4. Absence of active Periodontal disease
5. Good level of oral hygiene (Plaque index \<25%)
6. Absence of systemic diseases that could influence the outcome of the therapy (Uncontrolled diabetes, osteoporosis, bisphosphonate medications)
7. Non smokers or light smokers (\<10 cigarettes per day)
8. Informed consent signed

Exclusion Criteria:

1. Patients with sufficient ridge width (\>5 mm) and height (≥9mm) from vital anatomical structure) requiring no GBR to place dental implants
2. Patients with severe horizontal and vertical defects requiring other surgical techniques.
3. Long-term non-steroidal anti-inflammatory drug therapy (3months).
4. Lactating females or currently pregnant women.
5. Severe cognitive or psychiatric disorders.
6. Unwillingness to return for follow-up examination.

Where it's running

• Georgios Markantonatos
  Barcelona, Sant Cugat Del Vallès, Spain Recruiting

Study contacts

• Principal investigator: Cristina Vallés, DDS, MS, PhD — Universitat Internacional de Catalunya
• Study coordinator: Georgios Markantonatos, DDS
• Email: giorgosmark@uic.es
• Phone: +34666022568

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.