Comparing two types of bupivacaine for pain relief in wrist surgery
Official title: Randomized Controlled Trial of Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery
Run by University of North Carolina, Chapel Hill · NCT06179004 · Data updated 2026-11-12
This study is testing whether a new type of bupivacaine can provide better pain relief than the standard version for adults having wrist surgery.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of North Carolina, Chapel Hill Academic / other |
| Locations | 1 site (Chapel Hill, North Carolina) |
| Status | Recruiting |
| Started | April 10, 2024 |
| Main results expected | October 2026 |
| Study ends | October 2026 |
| Registry record updated | October 24, 2025 |
| Trial ID | NCT06179004 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older scheduled for distal radius fracture repair at the University of North Carolina.
✕Probably not a fit
Patients with contraindications to regional anesthesia, significant peripheral neuropathy, or those who are pregnant may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effectiveness of liposomal bupivacaine compared to standard bupivacaine in providing pain relief for patients undergoing orthopedic wrist surgery, specifically distal radius fracture repair. The study will involve adult participants over the age of 18 at the University of North Carolina, where a supraclavicular nerve block will be administered to assess postoperative pain management. By rigorously collecting perioperative data, the investigators hope to improve pain control and reduce variability in care practices at their institution.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies and reduced opioid use for patients undergoing wrist surgery.
How similar studies have gone: While liposomal bupivacaine has been approved for use, its specific efficacy in this context has limited data, making this study a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age greater than or equal to 18 * Scheduled for orthopedic wrist surgery at University of North Carolina at Chapel Hill. Exclusion Criteria: * Contraindications to regional anesthesia * Emergent surgery Open fractures will be treated emergently and will not allow adequate lead time for enrollment in this study. Also, open fractures are usually accompanied by other traumatic injuries that would confound the pain related outcomes in this study. * Significant peripheral neuropathy or neurological disorder affecting the upper extremity * Pregnancy Pregnant women have physiologic changes that make them more sensitive to local anesthetics. That would introduce a confounding element in interpreting the effectiveness of the peripheral nerve blocks being studied. * Cognitive or psychiatric condition that might affect patient assessment and/or inability to provide informed consent.
Where it's running
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UNC Chapel Hill
Chapel Hill, North Carolina, United States Recruiting
Study contacts
- Principal investigator: Jay Schoenherr, MD — University of North Carolina, Chapel Hill
- Study coordinator: Jay Schoenherr, MD
- Email: jay_schoenherr@med.unc.edu
- Phone: 9199515062
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Wrist Injury Strengthening Exercise added to usual care for improving pain and function after a wrist fracture
This trial tests whether a therapist-guided strengthening program helps people 50 and older recover better from a wrist fracture than standard self-management advice.
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This study will test whether cannulated screws or K-wires lead to better arm function and fewer complications in adults (18–60) with displaced extra-articular distal radius fractures.
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This trial will test whether adding Fu's subcutaneous needling to standard rehabilitation helps adults (18–85) heal distal radius fractures after closed reduction and splinting.
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Comparing two types of splints for wrist stiffness after a fracture
This study is testing which type of splint, static progressive or dynamic, helps adults with wrist stiffness after a fracture feel better and move their wrist more easily.
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Using mechanical devices to manage pain and swelling after wrist surgery
This study is testing whether using special machines to help with pain and swelling can improve recovery for people who have had wrist surgery for a broken bone.
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This study is testing three different rehab methods for wrist fractures in younger adults to see which one helps them recover better.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.