Comparing two types of bupivacaine for pain relief in wrist surgery
Randomized Controlled Trial of Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery
This study is testing whether a new type of bupivacaine can provide better pain relief than the standard version for adults having wrist surgery.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of North Carolina, Chapel Hill Academic / other |
| Locations | 1 site (Chapel Hill, North Carolina) |
| Trial ID | NCT06179004 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of liposomal bupivacaine compared to standard bupivacaine in providing pain relief for patients undergoing orthopedic wrist surgery, specifically distal radius fracture repair. The study will involve adult participants over the age of 18 at the University of North Carolina, where a supraclavicular nerve block will be administered to assess postoperative pain management. By rigorously collecting perioperative data, the investigators hope to improve pain control and reduce variability in care practices at their institution.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older scheduled for distal radius fracture repair at the University of North Carolina.
Not a fit: Patients with contraindications to regional anesthesia, significant peripheral neuropathy, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies and reduced opioid use for patients undergoing wrist surgery.
How similar studies have performed: While liposomal bupivacaine has been approved for use, its specific efficacy in this context has limited data, making this study a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age greater than or equal to 18 * Scheduled for orthopedic wrist surgery at University of North Carolina at Chapel Hill. Exclusion Criteria: * Contraindications to regional anesthesia * Emergent surgery Open fractures will be treated emergently and will not allow adequate lead time for enrollment in this study. Also, open fractures are usually accompanied by other traumatic injuries that would confound the pain related outcomes in this study. * Significant peripheral neuropathy or neurological disorder affecting the upper extremity * Pregnancy Pregnant women have physiologic changes that make them more sensitive to local anesthetics. That would introduce a confounding element in interpreting the effectiveness of the peripheral nerve blocks being studied. * Cognitive or psychiatric condition that might affect patient assessment and/or inability to provide informed consent.
Where this trial is running
Chapel Hill, North Carolina
- UNC Chapel Hill — Chapel Hill, North Carolina, United States (Recruiting)
Study contacts
- Principal investigator: Jay Schoenherr, MD — University of North Carolina, Chapel Hill
- Study coordinator: Jay Schoenherr, MD
- Email: jay_schoenherr@med.unc.edu
- Phone: 9199515062
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.