Clinical trial Recruiting at 1 site Phase 3 Interventional Ages 18 and up

Comparing two types of bupivacaine for pain relief in wrist surgery

Official title: Randomized Controlled Trial of Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery

Run by University of North Carolina, Chapel Hill · NCT06179004 · Data updated 2026-11-12

This study is testing whether a new type of bupivacaine can provide better pain relief than the standard version for adults having wrist surgery.

More Distal Radius Fractures trials

Quick facts

PhasePhase 3
Study typeInterventional
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorUniversity of North Carolina, Chapel Hill
Academic / other
Locations1 site (Chapel Hill, North Carolina)
StatusRecruiting
StartedApril 10, 2024
Main results expectedOctober 2026
Study endsOctober 2026
Registry record updatedOctober 24, 2025
Trial IDNCT06179004 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older scheduled for distal radius fracture repair at the University of North Carolina.

Probably not a fit

Patients with contraindications to regional anesthesia, significant peripheral neuropathy, or those who are pregnant may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of liposomal bupivacaine compared to standard bupivacaine in providing pain relief for patients undergoing orthopedic wrist surgery, specifically distal radius fracture repair. The study will involve adult participants over the age of 18 at the University of North Carolina, where a supraclavicular nerve block will be administered to assess postoperative pain management. By rigorously collecting perioperative data, the investigators hope to improve pain control and reduce variability in care practices at their institution.

Why it matters

Potential benefit: If successful, this study could lead to improved pain management strategies and reduced opioid use for patients undergoing wrist surgery.

How similar studies have gone: While liposomal bupivacaine has been approved for use, its specific efficacy in this context has limited data, making this study a novel approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age greater than or equal to 18
* Scheduled for orthopedic wrist surgery at University of North Carolina at Chapel Hill.

Exclusion Criteria:

* Contraindications to regional anesthesia
* Emergent surgery Open fractures will be treated emergently and will not allow adequate lead time for enrollment in this study. Also, open fractures are usually accompanied by other traumatic injuries that would confound the pain related outcomes in this study.
* Significant peripheral neuropathy or neurological disorder affecting the upper extremity
* Pregnancy Pregnant women have physiologic changes that make them more sensitive to local anesthetics. That would introduce a confounding element in interpreting the effectiveness of the peripheral nerve blocks being studied.
* Cognitive or psychiatric condition that might affect patient assessment and/or inability to provide informed consent.

Where it's running

  • UNC Chapel Hill
    Chapel Hill, North Carolina, United States
    Recruiting

Study contacts

  • Principal investigator: Jay Schoenherr, MD — University of North Carolina, Chapel Hill
  • Study coordinator: Jay Schoenherr, MD
  • Email: jay_schoenherr@med.unc.edu
  • Phone: 9199515062

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.