Comparing two treatments for improving nasolabial folds

A Single Center, Prospective, Comparative, Randomized, Double-blinded(Subject, Evaluator), Non-inferiority, Pivotal Clinical Study to Evaluate the Efficacy and Safety of the Polydioxanone Suture 'BRFS-18G-S100WH' Compared to 'MINT Lift FINE+' for Correction of the Nasolabial Folds

Not applicable Interventional Hugel · NCT06216418

This study is testing a new facial treatment to see if it can improve wrinkles around the mouth better than a current option for people with nasolabial folds.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment106 (estimated)
Ages19 Years and up
SexAll
SponsorHugel Industry-sponsored
Locations1 site (Seoul)
Trial IDNCT06216418 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the safety and efficacy of a new facial tissue fixing material called 'BRFS-18G-S100WH' in comparison to the existing treatment 'MINT Lift FINE+' for patients with nasolabial folds. Participants will undergo a procedure aimed at temporarily improving the appearance of these wrinkles using the two different materials. The study aims to determine if 'BRFS-18G-S100WH' provides a similar or better wrinkle improvement effect while ensuring safety for the patients involved.

Who should consider this trial

Good fit: Ideal candidates are adults over 19 years old with moderate to severe nasolabial folds who wish to improve their appearance.

Not a fit: Patients who have previously undergone facial procedures using fillers or fixation threads may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could offer patients a new effective option for temporarily reducing nasolabial folds.

How similar studies have performed: While this approach is being tested in this specific context, similar studies have shown promising results with facial tissue lifting techniques.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Adults over 19 years of age
2. Those who wish to temporarily improve nasolabial folds on both sides of the face and have a score of 3 (Moderate) or 4 (Severe) on the WSRS (Wrinkle Severity Rating Scale)
3. Those who voluntarily decided to participate in this clinical trial and agreed to the subject description and consent form in writing

Exclusion Criteria:

1. A person who has undergone a procedure using filler or facial tissue fixation thread on the facial area.
2. Those who are pregnant or lactating

Where this trial is running

Seoul

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Nasolabial Folds
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.