Comparing two treatments for advanced pancreatic cancer

Randomized Phase II Study of NaliCap (Irinotecan Liposome/Capecitabine) Compared to NAPOLI (Irinotecan Liposome/5-fluorouracil/Leucovorin) in Gemcitabine-pretreated Advanced Pancreatic Cancer

This study is testing if a new pill treatment for advanced pancreatic cancer can work as well or better than the standard treatment that uses an IV.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 200 (estimated)
• Ages: 20 Years and up
• Sex: All
• Sponsor: Seoul National University Hospital (Academic / other)
• Drugs / interventions: chemotherapy, immunotherapy
• Locations: 2 sites (Seongnam-si and 1 other locations)
• Trial ID: NCT04371224 on ClinicalTrials.gov

What this trial studies

This open-label, randomized phase 2 study evaluates the safety and efficacy of NaliCap, a combination of irinotecan liposome and capecitabine, against the standard NAPOLI regimen, which includes irinotecan liposome, 5-fluorouracil, and leucovorin, in patients with advanced pancreatic cancer who have previously been treated with gemcitabine. The study aims to determine if the oral administration of capecitabine can provide similar or improved outcomes compared to intravenous 5-FU. Participants will be monitored for overall survival and treatment tolerability throughout the trial.

Who should consider this trial

Good fit: Ideal candidates are adults over 20 years old with histologically confirmed advanced pancreatic ductal adenocarcinoma who have been previously treated with gemcitabine.

Not a fit: Patients with resectable pancreatic cancer or those who have not been treated with gemcitabine may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could offer a more convenient oral treatment option for patients with advanced pancreatic cancer, potentially improving their quality of life.

How similar studies have performed: While the NAPOLI regimen has shown success in previous studies, the combination of nal-IRI with capecitabine is a novel approach that has not yet been tested.

Eligibility criteria

Inclusion Criteria:

1. Signed informed consent
2. Age\>20 years at time of study entry
3. Histologically confirmed pancreatic ductal adenocarcinoma
4. Advanced stage (unresectable, recurrent)
5. Gemcitabine-pretreated for advanced pancreatic cancer
6. Eastern Cooperative Oncology Group(ECOG) performance status 0, 1
7. Adequate organ function
8. Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal subjects.
9. Subject is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up.

Exclusion Criteria:

1. Participation in another clinical study with an investigational product (IP) during the last 3 weeks
2. Concurrent enrolment in another clinical study, unless it is an observational (non-interventional) clinical study or during the follow-up period of an interventional study
3. Receipt of the last dose of anti-cancer therapy (chemotherapy, immunotherapy, endocrine therapy, targeted therapy, biologic therapy, tumor embolization, monoclonal antibodies, other investigational agent) 28 days prior to the first dose of study drug
4. Major surgical procedure (as defined by the Investigator) within 28 days prior to the first dose of IP. Note: Local surgery of isolated lesions for palliative intent is acceptable.
5. Known brain metastasis or spinal cord compression.
6. History of allogenic organ transplantation
7. Cardiac event during past 6 months
8. Uncontrolled intercurrent illness, including but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, cardiac arrhythmia, interstitial lung disease, serious chronic gastrointestinal conditions associated with diarrhea, or psychiatric illness/social situations that would limit compliance with study requirement, substantially increase risk of incurring AEs or compromise the ability of the patient to give written informed consent
9. Active infection including tuberculosis (TB) (clinical evaluation that includes clinical history, physical examination and radiographic findings, and TB testing in line with local practice), hepatitis B (known positive hepatitis B virus (HBV) surface antigen (HBsAg) result), hepatitis C, or human immunodeficiency virus (positive HIV 1/2 antibodies). Subjects with a past or resolved HBV infection (defined as the presence of hepatitis B core antibody \[anti-HBc (hepatitis B core antigen)\] and absence of HBsAg) are eligible. Subjects positive for hepatitis C (HCV) antibody are eligible only if polymerase chain reaction is negative for HCV RNA.
10. Female subjects who are pregnant or breastfeeding or male or female subjects of reproductive potential who are not willing to employ effective birth control from screening to 90 days after the last dose of IP.
11. Known allergy or hypersensitivity to any of the study drugs or any of the study drug excipients.
12. Judgment by the investigator that the patient is unsuitable to participate in the study and the patient is unlikely to comply with study procedures, restrictions and requirements.

Where this trial is running

Seongnam-si and 1 other locations

• Seoul National University Bundang Hospital — Seongnam-si, Korea, Republic of (Recruiting)
• Seoul National University Hospital — Seoul, Korea, Republic of (Recruiting)

Study contacts

• Study coordinator: Do-Youn Oh, M.D., PhD.

Conditions Pancreatic Cancer