Comparing two therapies for veterans with social anxiety disorder

A Randomized Clinical Trial Comparing Transdiagnostic Behavior Therapy to Disorder-Specific Psychotherapy in the Recovery of Veterans With Social Anxiety Disorder and Comorbid PTSD Symptomatology

Not applicable Interventional VA Office of Research and Development · NCT05858346

This study is testing whether a new therapy for social anxiety can help veterans feel better compared to the usual therapy they receive.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment264 (estimated)
Ages18 Years to 80 Years
SexAll
SponsorVA Office of Research and Development Federal
Locations1 site (Charleston, South Carolina)
Trial IDNCT05858346 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of Transdiagnostic Behavior Therapy (TBT) compared to traditional Cognitive Behavioral Therapy (CBT) specifically for veterans suffering from social anxiety disorder (SAD) and comorbid posttraumatic stress disorder (PTSD). The research employs a randomized controlled trial design, assessing psychiatric symptoms and quality of life at multiple time points, including pre-treatment, mid-treatment, post-treatment, and at a 6-month follow-up. Veterans will be recruited from various mental health programs within the Charleston VA Health Care System, and their participation will involve a thorough intake process to ensure eligibility. The study aims to improve psychological well-being and social reintegration for participants.

Who should consider this trial

Good fit: Ideal candidates are veterans registered at the Ralph H. Johnson Veterans Affairs Health Care System who meet the criteria for social anxiety disorder and have significant PTSD symptoms.

Not a fit: Patients with recent psychiatric hospitalizations, severe medical conditions, or primary diagnoses of psychotic disorders, personality disorders, substance use disorders, or bipolar disorder may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a more efficient and accessible treatment option for veterans with social anxiety disorder and PTSD.

How similar studies have performed: Other studies have shown promise in using transdiagnostic approaches for treating anxiety disorders, suggesting potential success for this novel application.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Participants must be Veterans and registered at Ralph H. Johnson Veterans Affairs Health Care System
* Participants must be clearly competent to provide informed consent for research participation
* Participants must meet DSM-5 criteria for social anxiety disorder
* Participants must have clinically significant symptoms of comorbid posttraumatic stress

Exclusion Criteria:

* recent history (\< 2 months) of psychiatric hospitalization or a suicide attempt as documented in their medical record,
* acute, severe illness or medical condition that likely will interfere with study procedures as documented in their medical record
* recent start of new psychiatric medication(s) (\< 4 weeks),
* primary diagnosis of a condition associated with psychotic symptoms, personality disorder, substance use disorder, or bipolar disorder.

Where this trial is running

Charleston, South Carolina

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Social Anxiety Disorder
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.