Comparing two techniques for harvesting the left internal thoracic artery in heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of two different techniques for harvesting the left internal thoracic artery (LITA) on graft patency rates and patient survival in individuals undergoing coronary artery bypass grafting (CABG). The study is a prospective, randomized, multi-centre trial that aims to determine whether the skeletonized or pedicled harvesting technique yields better clinical outcomes. By comparing these techniques, the trial seeks to provide evidence that could influence surgical practices and improve patient care in coronary artery disease. Participants will be carefully selected based on specific inclusion and exclusion criteria to ensure the validity of the results.

Why it matters

Who can join: the full rules

Inclusion criteria:

Primary isolated CABG patients with multi-vessel disease (defined as ≥70 % stenosis of the left anterior descending artery (LAD) and ≥50% stenosis of circumflex and right coronary territory, with or without a ≥50% stenosis of the left main artery).

Exclusion criteria:

* Age \> 80 years
* Planned CABG without LITA use
* Preoperative mediastinal radiation therapy
* Emergency operation
* Minimal invasive coronary artery bypass surgery
* Any concomitant cardiac or non-cardiac procedures
* Previous cardiac surgery
* Known contrast agent allergy
* Severe stenosis of the left subclavian artery/ left-sided subclavian steal syndrome
* Chronic kidney disease (GFR \<60ml/min/1.73m²)
* Life expectancy of less than 5 years
* Pregnancy
* Hyperthyroidism
* Iodine allergy

Intraoperative exclusion criteria:

* Y/T graft off the LITA graft
* LITA sequential grafting
* LITA target vessel other than LAD

Where it's running

• Medical University of Innsbruck
  Innsbruck, Austria Recruiting
• Medical University of Graz
  Graz, Austria Not yet recruiting
• Medical University of Vienna
  Vienna, Austria Not yet recruiting
• University of Duisburg-Essen
  Essen, Germany Not yet recruiting
• University of Freiburg
  Freiburg im Breisgau, Germany Not yet recruiting
• University Hospital Gießen
  Giessen, Germany Not yet recruiting

Study contacts

• Principal investigator: Hannes Abfalterer, Dr. med. univ. — Medical University Innsbruck
• Study coordinator: Hannes Abfalterer, Dr. med. univ.
• Email: hannes.abfalterer@i-med.ac.at
• Phone: 004351250482988

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.