Comparing two techniques for clearing mucus in patients on mechanical ventilation
Official title: Evaluating the Short-term Efficacy of Two Oscillation Techniques in Hypersecretive Mechanically Ventilated Patients: a Randomized Crossover Trial
Run by Capital Medical University · NCT06675942 · Data updated 2026-11-12
This study is testing two different ways to help clear mucus from the lungs of patients on mechanical ventilation to see which method works better for their breathing.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | Capital Medical University Academic / other |
| Locations | 1 site (Beijing) |
| Status | Recruiting |
| Started | November 10, 2024 |
| Main results expected | December 2, 2024 |
| Study ends | February 13, 2025 |
| Registry record updated | January 22, 2025 |
| Trial ID | NCT06675942 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with airway hypersecretion who require more than 48 hours of mechanical ventilation in an ICU setting.
✕Probably not a fit
Patients with conditions such as malignant arrhythmia, acute myocardial ischemia, or other severe lung diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of two airway clearance techniques, oscillation and lung expansion (OLE) and high-frequency chest wall oscillation (HFCWO), in improving lung aeration and ventilation distribution in hypersecretive patients requiring long-term mechanical ventilation. It is a randomized cross-over study involving patients with tracheostomy tubes who have been admitted to the ICU and are experiencing airway hypersecretion. The study aims to establish a more effective method for mucus removal, which is crucial for preventing complications such as pneumonia and atelectasis in these patients.
Why it matters
Potential benefit: If successful, this study could lead to improved airway clearance techniques, reducing the risk of pneumonia and enhancing recovery in mechanically ventilated patients.
How similar studies have gone: While there is ongoing research in airway clearance techniques, this specific comparison of OLE and HFCWO in this patient population is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Eligible participants were patients aged ≥18 years with airway hypersecretion, admitted to the ICU, * Requiring more than 48 hours of MV. Exclusion Criteria: * Malignant arrhythmia * Acute myocardial ischemia * Pneumothorax, pulmonary bulla, barotrauma, or other lung diseases, * Hemorrhagic disease or coagulation abnormalities with bleeding tendencies * Skin trauma on the chest * Pulmonary embolism * Presence of a permanent or temporary pacemaker * Untreated spinal and rib fractures * Any condition deemed inappropriate for study inclusion by the researchers.
Where it's running
-
Beijing Rehabilitation Hospital
Beijing, China Recruiting
Study contacts
- Principal investigator: Jingyi Ge — Beijing Rehabilitation Hospital of Capital Medical University
- Study coordinator: Jingyi Ge
- Email: ge_jingyi2020@163.com
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.