Comparing two techniques for clearing mucus in patients on mechanical ventilation
Evaluating the Short-term Efficacy of Two Oscillation Techniques in Hypersecretive Mechanically Ventilated Patients: a Randomized Crossover Trial
This study is testing two different ways to help clear mucus from the lungs of patients on mechanical ventilation to see which method works better for their breathing.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Capital Medical University Academic / other |
| Locations | 1 site (Beijing) |
| Trial ID | NCT06675942 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of two airway clearance techniques, oscillation and lung expansion (OLE) and high-frequency chest wall oscillation (HFCWO), in improving lung aeration and ventilation distribution in hypersecretive patients requiring long-term mechanical ventilation. It is a randomized cross-over study involving patients with tracheostomy tubes who have been admitted to the ICU and are experiencing airway hypersecretion. The study aims to establish a more effective method for mucus removal, which is crucial for preventing complications such as pneumonia and atelectasis in these patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with airway hypersecretion who require more than 48 hours of mechanical ventilation in an ICU setting.
Not a fit: Patients with conditions such as malignant arrhythmia, acute myocardial ischemia, or other severe lung diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved airway clearance techniques, reducing the risk of pneumonia and enhancing recovery in mechanically ventilated patients.
How similar studies have performed: While there is ongoing research in airway clearance techniques, this specific comparison of OLE and HFCWO in this patient population is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Eligible participants were patients aged ≥18 years with airway hypersecretion, admitted to the ICU, * Requiring more than 48 hours of MV. Exclusion Criteria: * Malignant arrhythmia * Acute myocardial ischemia * Pneumothorax, pulmonary bulla, barotrauma, or other lung diseases, * Hemorrhagic disease or coagulation abnormalities with bleeding tendencies * Skin trauma on the chest * Pulmonary embolism * Presence of a permanent or temporary pacemaker * Untreated spinal and rib fractures * Any condition deemed inappropriate for study inclusion by the researchers.
Where this trial is running
Beijing
- Beijing Rehabilitation Hospital — Beijing, China (Recruiting)
Study contacts
- Principal investigator: Jingyi Ge — Beijing Rehabilitation Hospital of Capital Medical University
- Study coordinator: Jingyi Ge
- Email: ge_jingyi2020@163.com
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.