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Comparing two surgical methods for colon cancer treatment

Laparoscopic Ileocecal-Sparing Right Hemicolectomy for Cancer of the Hepatic Flexure and Proximal Transverse Colon -- A Prospective, Multicenter Randomized Control Clinical Trial

Not applicable Interventional Zhejiang University · NCT05923255

This study is testing whether a new type of colon cancer surgery called Laparoscopic Ileocecal-Sparing Right Hemicolectomy can lead to better long-term results than the traditional surgery for patients with specific types of colon cancer.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment568 (estimated)
Ages18 Years to 75 Years
SexAll
SponsorZhejiang University Academic / other
Locations29 sites (Bengbu, Anhui and 28 other locations)
Trial IDNCT05923255 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to evaluate the long-term outcomes of Laparoscopic Ileocecal-Sparing Right Hemicolectomy (LISH) versus Traditional Laparoscopic Right Hemicolectomy (TRH) in patients with hepatic flexure and proximal transverse colon cancer. It is a prospective, multicenter, open-labeled, randomized controlled trial where participants will be randomly assigned to one of the two surgical approaches. The primary endpoint is the 3-year disease-free survival rate, while secondary endpoints include postoperative complications, pathology-related indicators, and the 5-year overall survival rate. The study seeks to determine if LISH offers better outcomes compared to TRH.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18-75 with confirmed colon adenocarcinoma located in the hepatic flexure or proximal transverse colon.

Not a fit: Patients with synchronous multiple primary colorectal cancers or those requiring additional radical surgery may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved surgical outcomes and survival rates for patients with specific types of colon cancer.

How similar studies have performed: Other studies have shown promising results with laparoscopic techniques, but this specific comparison of LISH and TRH is novel.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Age between 18-75 years old
2. ASA classification ≤III
3. Colon adenocarcinoma confirmed by endoscopy and pathological biopsy
4. Enhanced abdominal CT indicating the primary lesion is located in the hepatic flexure of the colon or proximal transverse colon (proximal 1/3 of the transverse colon)
5. Preoperative clinical staging: TanyNanyM0
6. Patients able to understand the study protocol, willing to participate in the research, and providing written informed consent

Exclusion Criteria:

1. Preoperative examination indicates synchronous multiple primary colorectal cancers or other diseases requiring bowel segment resection
2. Preoperative imaging or intraoperative exploration reveals: 1) tumor involving surrounding organs requiring combined organ resection; 2) presence of distant metastasis; 3) inability to perform R0 resection; 4) fused and fixed lymph nodes at the root of the ileocolic vessels
3. Additional radical surgery following Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD) procedures
4. History of any other malignant tumor within the last 5 years or familial adenomatous polyposis, except for cured in situ cervical cancer, basal cell carcinoma, papillary thyroid carcinoma, or skin squamous cell carcinoma
5. Presence of bowel obstruction, bowel perforation, or intestinal bleeding requiring emergency surgery
6. Patients unsuitable for or unable to tolerate laparoscopic surgery
7. Pregnant or lactating women
8. Patients with a history of psychiatric disorders
9. Patients who have received neoadjuvant therapy prior to surgery
10. Patients deemed unsuitable for the study by MDT discussion
11. Patients unable to understand the study's conditions and objectives, and refusing to sign informed consent.

Where this trial is running

Bengbu, Anhui and 28 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Hepatic Flexure Colon CancerProximal Transverse Colon Cancerhepatic flexure colon cancerproximal transverse colon cancerileocecus-sparinglaparoscopic right hemicolectomy
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.