Comparing two surgical approaches for spinal oligometastatic tumors with radiotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of En bloc surgery versus separation surgery combined with radiotherapy on the survival and prognosis of patients with spinal oligometastatic cancer. It aims to determine the clinical outcomes of these treatment approaches and optimize future treatment strategies. Patients with oligometastatic disease, characterized by limited metastatic spread, may benefit from more aggressive local treatments, including surgery and targeted radiotherapy. The study will analyze the impact of these interventions on patient survival and quality of life.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\) Be able to sign written informed consent.
* 2\) Age range from 18 to 75 years old, regardless of gender.
* 3\) Within conservative treatment, the patient still has uncontrollable pain, metastatic cancer lesions that still progress, spinal instability/potential instability, or symptoms of spinal cord/nerve compression.
* 4\) After the patient underwent Positron Emission Tomography-Computed Tomography (PET-CT) examination, it was indicated that there were no more than 3 metastatic organs and no more than 5 metastatic lesions in the whole body of cancer. Among them, there was at least 1 spinal metastasis and at most 5 spinal metastases.
* 5\) Imaging examinations (enhanced MRI, enhanced CT, X-ray) indicate the presence of spinal metastasis.
* 6\) The expected survival period is ≥ 6 months.
* 7)No other surgical contraindications

Exclusion Criteria:

* 1\) Primary tumors of the spine or multiple tumors of the body, with\>3 metastatic organs and\>5 metastatic sites.
* 2\) Previously underwent spinal surgery, or received radiotherapy for the responsible segment of this treatment.
* 3\) Severe heart, lung, liver, kidney or other diseases affecting the surgery.
* 4\) Having cognitive impairment, sensory aphasia, and inability to understand basic instructions.
* 5\) Participated in clinical trials of other drugs or medical devices within 3 months prior to enrollment.
* 6\) Infectious diseases.
* 7\) Refuse to follow up or participate.
* 8\) The researchers determine that the patients are not suitable for enrollment this clinical trail.

Where it's running

• Shanghai Changzheng hospital
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Jianru Xiao, Doctor
• Email: jianruxiao83@163.com
• Phone: +86 13701785283

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.