Home › Trials › NCT05155501
Clinical trial Recruiting at 9 sites Interventional Ages 40 to 80 Men only

Comparing two surgical approaches for prostate cancer treatment

Official title: Clinical TrIAL of Approaches to Prostate cAncer suRgery

Run by Weill Medical College of Cornell University · NCT05155501 · Data updated 2026-11-12

This study is testing whether a new type of prostate surgery that spares more tissue can help men with localized prostate cancer have better cancer control and quality of life compared to the standard surgery.

Quick facts

Study typeInterventional
Ages40 Years to 80 Years
SexMen only
Enrollment600 (estimated)
SponsorWeill Medical College of Cornell University
Academic / other
Locations9 sites (Duarte, California and 8 other locations)
StatusRecruiting
StartedMay 15, 2023
Main results expectedJuly 2028
Study endsJuly 2028
Registry record updatedApril 22, 2026
Trial IDNCT05155501 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adult men aged 40 to 80 who are scheduled for radical prostatectomy due to clinically localized prostate cancer.

Probably not a fit

Patients with prior major pelvic surgery or radiotherapy, or those suspected of having lymph node involvement, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial is a prospective, randomized controlled trial designed to compare the outcomes of pelvic fascia-sparing radical prostatectomy with standard radical prostatectomy in men diagnosed with clinically localized prostate cancer. The study aims to evaluate cancer control and health-related quality of life, focusing on urinary function, sexual function, and risks of complications such as penile shortening and inguinal hernia. Participants will be randomly assigned to one of the two surgical approaches, and outcomes will be assessed through patient questionnaires and medical record reviews.

Why it matters

Potential benefit: If successful, this study could lead to improved surgical outcomes and quality of life for patients undergoing prostate cancer surgery.

How similar studies have gone: Other studies have shown promising results with similar surgical approaches, suggesting potential for success in this trial.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Male sex
* Age ≥40 years or ≤80 years
* Scheduled for radical prostatectomy for clinically localized prostate cancer
* Able to read and speak English or Spanish
* Willingness to sign informed consent and adhere to the study protocol

Exclusion Criteria:

* Prior major pelvic surgery or radiotherapy
* Suspicion of N1 disease (i.e., any lymph node greater than 1cm in maximal diameter)

Where it's running

  • Beckman Research Institute of City of Hope
    Duarte, California, United States     Recruiting
  • Georgetown University
    Washington D.C., District of Columbia, United States     Recruiting
  • Northwestern University
    Chicago, Illinois, United States     Recruiting
  • Johns Hopkins University
    Baltimore, Maryland, United States     Recruiting
  • Beth Israel Deaconess Medical Center (BIDMC)
    Boston, Massachusetts, United States     Recruiting
  • Hackensack Meridian Health
    Hackensack, New Jersey, United States     Recruiting
Show 3 more locations
  • NewYork-Presbyterian Queens
    Flushing, New York, United States     Recruiting
  • Memorial Sloan Kettering Cancer Center
    New York, New York, United States     Recruiting
  • Weill Cornell Medicine
    New York, New York, United States     Recruiting

Study contacts

  • Principal investigator: Jim C Hu, MD, MPH — Weill Medical College of Cornell University
  • Study coordinator: May Ting, MBS
  • Email: mat7051@med.cornell.edu
  • Phone: 732-757-2448

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
Browse more
Prostate Cancer 1464Weill Medical College of Cornell University 137
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.