Comparing two protocols for ovarian stimulation in IVF for Vietnamese women
Evaluate the Effectiveness of Progestin-Primed Versus GnRH Antagonist Protocols in Vietnamese Women Undergoing In-vitro Fertilization: A Randomized Controlled Trial
This study is testing whether a new ovarian stimulation method for IVF works better than the standard method for Vietnamese women trying to conceive.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 20 Years to 45 Years |
| Sex | Female |
| Sponsor | Hanoi Medical University Academic / other |
| Locations | 1 site (Ho Chi Minh City) |
| Trial ID | NCT06191809 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of the progestin-primed ovarian stimulation (PPOS) protocol against the standard GnRH antagonist protocol in women undergoing in-vitro fertilization (IVF). Conducted as an open-label, randomized controlled trial, it aims to determine the difference in the number of retrieved oocytes between the two protocols. The study will involve 200 participants, with 100 women receiving each treatment, and will take place at the Assisted Reproduction Center of Tam Anh General Hospital and Hanoi Medical University. The trial is designed to provide insights into optimizing IVF protocols for better outcomes.
Who should consider this trial
Good fit: Ideal candidates are women aged 20 to 45 experiencing infertility due to male factors, fallopian tube issues, or unknown causes.
Not a fit: Patients with contraindications to ovarian stimulation, systemic diseases, or those who have taken hormone drugs recently may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved IVF success rates for women undergoing treatment.
How similar studies have performed: Previous studies have shown varying success with different ovarian stimulation protocols, making this approach both relevant and necessary for further exploration.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Women meeting the sample selection criteria are as follows: * Women age 20 to 45 years old. * Infertility due to male factors, fallopian tube factors, or unknown causes. * Undergoing IVF in one COS cycle and intended to apply either GnRH antagonist protocol or PPOS protocol * Voluntary participation in research. Exclusion Criteria: * Any contraindications to ovarian stimulation and IVF/ICSI treatment * Hyperprolactinemia or other endocrine diseases. * Those who took hormone drugs within the past 3 months * Suffering from systemic diseases such as kidney failure, lupus erythematosus, depression, etc. * Abnormal structure of the uterine cavity. * Patients with endometriosis or cancer * Random-start cycles. * Oocyte donation cycles * Perform embryo biopsy.
Where this trial is running
Ho Chi Minh City
- Univesity of Medicine and Pharmacy at Ho Chi Minh City — Ho Chi Minh City, Vietnam (Recruiting)
Study contacts
- Principal investigator: Thach Than Trong — Hanoi Medical University
- Study coordinator: Thach Than Trong
- Email: thachthan007@gmail.com
- Phone: +84908400040
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.