Comparing two physiotherapy techniques for COPD patients on mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effects of manual hyperinflation and diaphragmatic proprioceptive neuromuscular facilitation on pulmonary functions in male patients with acute exacerbations of COPD who are on mechanical ventilation. Sixty patients aged 50 to 60 will be randomly assigned to three groups: one receiving manual hyperinflation, another receiving proprioceptive neuromuscular facilitation, and a control group. The study will utilize pre-post measures and a single-blinded, randomized controlled design to assess the effectiveness of these interventions on arterial blood gases and overall pulmonary function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients will be included in the study if they have the following criteria:

  1. Sixty male mechanically ventilated patients. They will be ventilated on pressure support (PS) mode of MV with this setting (Positive end-expiratory pressure \[PEEP\]) less than 8 cm H2O, FiO2 0.4 or less, SpO2 higher than 90) due to AECOPD.
  2. Their Glasgow Coma Scale score will be ranged from 13 to 15.
  3. Their age between 50 and 60 years old.
  4. Their BMI will be ranged from 25 to 34.9 kg/m2.
  5. Moderate (GOLD 2) and severe (GOLD 3) stages of COPD according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) grading system for the severity of COPD.

Exclusion Criteria:

* The patients will be excluded from this study if they have one of the following criteria:

Fever above 38.3 °C. Unstable hemodynamics. Thoracic or abdominal surgery that preclude the use of PNF exercises. Chest trauma such as rib fracture, flail chest and thoracic vertebra fracture or chest burns.

Peripheral and central nervous system diseases. Active lung infection like tuberculosis. Active bleeding as alveolar hemorrhage, hemoptysis. Spinal cord injuries involved the phrenic nerve. Severe cardiac complications due to COPD.

Where it's running

• Gamal Abdelnasser Hospital
  Alexandria, Aleksandria, Egypt Recruiting

Study contacts

• Study coordinator: omar hesham, Bsc
• Email: ohesham1995@gmail.com
• Phone: 01116654844

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.