Comparing two physiotherapy techniques for COPD patients on mechanical ventilation

Manual Hyperinflation Versus Diaphragmatic Proprioceptive Neuromuscular Facilitation on Pulmonary Functions in Mechanically Ventilated Patients

This study tests which of two physiotherapy techniques helps men with COPD on mechanical ventilation breathe better during their recovery.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 60 (estimated)
• Ages: 50 Years to 60 Years
• Sex: Male
• Sponsor: Cairo University (other)
• Locations: 1 site (Alexandria, Aleksandria)
• Trial ID: NCT06221033 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to compare the effects of manual hyperinflation and diaphragmatic proprioceptive neuromuscular facilitation on pulmonary functions in male patients with acute exacerbations of COPD who are on mechanical ventilation. Sixty patients aged 50 to 60 will be randomly assigned to three groups: one receiving manual hyperinflation, another receiving proprioceptive neuromuscular facilitation, and a control group. The study will utilize pre-post measures and a single-blinded, randomized controlled design to assess the effectiveness of these interventions on arterial blood gases and overall pulmonary function.

Who should consider this trial

Good fit: Ideal candidates are male patients aged 50 to 60 with moderate to severe COPD who are currently on mechanical ventilation.

Not a fit: Patients with unstable hemodynamics or recent thoracic or abdominal surgery may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve respiratory function and recovery outcomes for mechanically ventilated COPD patients.

How similar studies have performed: While similar physiotherapy approaches have been explored, this specific comparison of techniques in mechanically ventilated COPD patients is relatively novel.

Eligibility criteria

Inclusion Criteria:

* Patients will be included in the study if they have the following criteria:

  1. Sixty male mechanically ventilated patients. They will be ventilated on pressure support (PS) mode of MV with this setting (Positive end-expiratory pressure \[PEEP\]) less than 8 cm H2O, FiO2 0.4 or less, SpO2 higher than 90) due to AECOPD.
  2. Their Glasgow Coma Scale score will be ranged from 13 to 15.
  3. Their age between 50 and 60 years old.
  4. Their BMI will be ranged from 25 to 34.9 kg/m2.
  5. Moderate (GOLD 2) and severe (GOLD 3) stages of COPD according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) grading system for the severity of COPD.

Exclusion Criteria:

* The patients will be excluded from this study if they have one of the following criteria:

Fever above 38.3 °C. Unstable hemodynamics. Thoracic or abdominal surgery that preclude the use of PNF exercises. Chest trauma such as rib fracture, flail chest and thoracic vertebra fracture or chest burns.

Peripheral and central nervous system diseases. Active lung infection like tuberculosis. Active bleeding as alveolar hemorrhage, hemoptysis. Spinal cord injuries involved the phrenic nerve. Severe cardiac complications due to COPD.

Where this trial is running

Alexandria, Aleksandria

• Gamal Abdelnasser Hospital — Alexandria, Aleksandria, Egypt (RECRUITING)

Study contacts

• Study coordinator: omar hesham, Bsc

Conditions: COPD Exacerbation Acute