Comparing two nerve block techniques for pain management after knee amputation

Peri Capsular Nerve Group Block Versus Sciatico Femoral Block to Assess the Incidence of Post Amputation Syndroms in Patients Undergoing Above Knee Amputation Surgeries

Not applicable Interventional National Cancer Institute, Egypt · NCT05819879

This study is testing two different nerve block methods to see which one helps reduce pain and phantom sensations in people who have had a knee amputation.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment60 (estimated)
Ages20 Years to 60 Years
SexAll
SponsorNational Cancer Institute, Egypt Academic / other
Locations1 site (Cairo)
Trial IDNCT05819879 on ClinicalTrials.gov

What this trial studies

This study assesses the effectiveness of two different nerve block techniques, the peri-capsular nerve group (PENG) block and the sciatic femoral block, in reducing the incidence of post-amputation syndromes in patients undergoing above-knee amputation. The research focuses on preventing phantom sensations and pain that can arise after the loss of a limb. By utilizing ultrasound-guided techniques, the study aims to improve pain management and enhance rehabilitation outcomes for patients. Effective communication among the surgical and anesthetic teams is emphasized as a critical component for successful pain management.

Who should consider this trial

Good fit: Ideal candidates for this study are patients aged 20 to 60 years, classified as ASA class I or II, who are undergoing above-knee amputation due to cancer.

Not a fit: Patients with cognitive disorders, unstable cardiovascular disease, or those who refuse participation may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could significantly reduce the incidence of phantom pain and improve recovery for patients undergoing above-knee amputation.

How similar studies have performed: Other studies have shown promise in using nerve blocks for pain management in similar surgical contexts, suggesting that this approach may be effective.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* ASA class I and II
* Age above 20 and less than 60 years.
* Patients undergoing above knee amputation due to any type of cancer

Exclusion Criteria:

* Patient refusal.
* Local infection at the puncture site.
* Coagulopathy.
* Cognitive disorders.
* Unstable cardiovascular disease.
* History of psychiatric disorders.
* History of drug abuse.
* Patients allergic to medication used.

Where this trial is running

Cairo

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Femoral Nerve BlockAmputation of Knee
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.