Comparing two MRI techniques for assessing carotid artery plaques
Level of Agreement in the Assessment of Carotid Plaque Composition Between Multi-contrast and Multi-sequence MRI
This study is testing two new MRI techniques to see if they can better measure dangerous carotid artery plaques in patients, while making the scans quicker and more comfortable.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Maastricht University Medical Center Academic / other |
| Locations | 1 site (Maastricht, Limburg) |
| Trial ID | NCT04569006 on ClinicalTrials.gov |
What this trial studies
This observational study aims to validate two innovative multi-contrast MRI sequences, MATCH and BOOST, for quantifying atherosclerotic plaque components in comparison to traditional multi-sequence MRI and histology. The study focuses on patients with carotid artery plaques that are 2 mm or thicker, as these plaques pose a significant risk for stroke and myocardial infarction. By reducing the MRI scan time to under 6 minutes while maintaining high soft tissue contrast, the study seeks to improve patient comfort and clinical practicality. The study will involve a cross-sectional analysis of 40 patients to assess the effectiveness of these new imaging techniques.
Who should consider this trial
Good fit: Ideal candidates are patients aged 18 and older with carotid plaques measuring 2 mm or more.
Not a fit: Patients with smaller carotid plaques, severe co-morbidities, or contraindications for MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to faster and more accurate identification of high-risk atherosclerotic plaques, improving patient outcomes.
How similar studies have performed: While the approach of using multi-contrast sequences is innovative, similar studies have shown promise in improving MRI efficiency and accuracy in plaque characterization.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: In order to be eligible to participate in this study, a subject must meet the following criteria: * Patients with a carotid plaque ≥ 2 mm thick based on ultrasound or CTA * Age 18 years or older (no maximum age) * Informed consent by signing informed consent form regarding this study Exclusion Criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: * Patients with carotid plaque ≤ 2 mm in size based on ultrasound or CTA * Standard contra-indications for MRI (electronic implants like pacemakers or other electronic implants, metallic eye fragments, vascular clips, claustrophobia, etc.) * Severe co-morbidity, dementia or pregnancy
Where this trial is running
Maastricht, Limburg
- Maastricht University Medical Center — Maastricht, Limburg, Netherlands (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.