Comparing two methods to treat prolonged air leaks after lung surgery

Comparison of 40% Glucose Solution and Autologous Blood Patch Pleurodesis for Postoperative Air Leak After Lung Resections: Prospective Randomized Study

This study is testing whether a sugar solution or a blood patch works better to fix air leaks that happen after lung surgery in adults.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 200 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Wielkopolskie Centrum Pulmonologii i Torakochirurgii (Academic / other)
• Drugs / interventions: chemotherapy
• Locations: 1 site (Poznan, Wielkopolska)
• Trial ID: NCT06936969 on ClinicalTrials.gov

What this trial studies

This clinical trial compares the effectiveness of a 40% glucose solution and autologous blood patch pleurodesis in treating prolonged air leaks (PAL) that occur after lung surgeries such as lobectomy. PAL is a common complication that can lead to significant discomfort and complications for patients. The study will involve patients aged 18 and older who have undergone anatomical lung resections and have been diagnosed with PAL persisting beyond five days post-surgery. Participants will receive one of the two interventions to determine which is more effective in resolving the air leak.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older who have undergone anatomical lung resections and have a diagnosed prolonged air leak.

Not a fit: Patients who have undergone non-anatomical resections or have active infections or sepsis may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a more effective treatment option for patients suffering from prolonged air leaks after lung surgery.

How similar studies have performed: While there have been studies on pleurodesis techniques, this specific comparison of glucose solution versus autologous blood patch is novel.

Eligibility criteria

Inclusion Criteria:

* Age: patients aged 18 years or older.
* Surgical Procedure: patients who underwent anatomical lung resections (segmentectomy, lobectomy, or bilobectomy) at the Department of Thoracic Surgery, Poznan University of Medical Sciences, between November 2023 and December 2024.
* Prolonged Air Leak Diagnosis: patients with diagnosed PAL after lung resection, as defined by air leakage persisting beyond 5 days post-surgery.
* Consent: patients who were willing to provide informed consent for participation in the study and for the intervention procedures (autologous blood pleurodesis or 40% glucose solution pleurodesis).

Exclusion Criteria:

* Non-Anatomical Resections: Patients who underwent non-anatomical resections, such as pneumonectomy, lung transplantation, sleeve resections, or wedge resections.
* Patients from whom the required volume of peripheral blood (120 ml) could not be collected.
* Active Infection or Sepsis: Patients with ongoing infections or sepsis at the time of enrollment.
* Reoperation or Additional Interventions: patients who required immediate reoperation or other interventions that disturb the process of treating PAL.
* Mental Health or Cognitive Impairment: patients with significant cognitive impairments or mental health conditions that hinder the ability to provide informed consent or comply with study procedures.
* Patients who failed to perform three ABPP or 40% glucose injections (no consent, need for urgent surgery).

Where this trial is running

Poznan, Wielkopolska

• Wielkopolskie Centrum Pulmonologii i Torakochirurgii — Poznan, Wielkopolska, Poland (Recruiting)

Study contacts

• Study coordinator: Piotr Jerzy Skrzypczak, MD

Conditions Prolonged Air Leak; Persistent Air Leak; PAL; ABPP; Prolonged air leak; persistent air leak; lung cancer; anatomical lung resection