Clinical trial Recruiting at 1 site Interventional Ages 20 to 45

Comparing two methods to prevent infection in ACL reconstruction surgery

Official title: Parenteral Versus Combined Parenteral With Vancomycin-soaked Graft in Decreasing the Risk of Infection in ACL Reconstruction Surgery: A Randomized Controlled Trial

Run by University of Duhok · NCT06166381 · Data updated 2026-11-12

This study is testing whether using grafts soaked in vancomycin can better prevent infections after ACL surgery compared to regular antibiotics for patients aged 20 to 45.

Quick facts

Study typeInterventional
Ages20 Years to 45 Years
SexAll
Enrollment288 (estimated)
SponsorUniversity of Duhok
Academic / other
Locations1 site (Duhok)
StatusRecruiting
StartedJanuary 25, 2024
Main results expectedDecember 2024
Study endsFebruary 2025
Registry record updatedDecember 30, 2024
Trial IDNCT06166381 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals aged 20 to 45 with ACL injuries that affect their daily activities or sports.

Probably not a fit

Patients requiring revision ACL surgery or those with inflammatory rheumatological disorders may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of vancomycin-soaked autografts versus standard parenteral antibiotics in preventing infections following anterior cruciate ligament (ACL) reconstruction surgery. Patients aged 20 to 45 with ACL dysfunction will be randomly assigned to receive either standard antibiotics or antibiotics combined with vancomycin-soaked grafts. The study will assess the occurrence of post-operative infections to determine if the vancomycin-soaked method significantly reduces infection rates compared to the control group. Conducted at Azadi Teaching Hospital in Duhok, Iraq, this trial seeks to improve surgical outcomes for ACL reconstruction patients.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the risk of post-operative infections in patients undergoing ACL reconstruction.

How similar studies have gone: While the use of antibiotics in surgical procedures is common, the specific approach of using vancomycin-soaked grafts is novel and has not been extensively tested in ACL reconstruction.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* ACL injury that interferes with life activities and/or sports

Exclusion Criteria:

* Patients for revision surgery of ACL reconstruction
* patients with inflammatory rheumatological disorders
* Refusal to participate in the study.

Where it's running

  • College of Medicine/University of Duhok
    Duhok, Iraq
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.