Comparing two methods to measure intraocular lens tilt and decentration
Agreement and Reproducibility of Intraocular Lens Tilt and Decentration Measurements: A Comparison Between CASIA2 and CILT
This tests two imaging methods to see which more reliably measures intraocular lens tilt and decentration in people planning cataract surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 15 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | St John of God Hospital, Vienna Academic / other |
| Locations | 1 site (Vienna, State of Vienna) |
| Trial ID | NCT07025707 on ClinicalTrials.gov |
What this trial studies
This prospective observational study compares measurements of intraocular lens (IOL) tilt and decentration obtained with the CASIA2 anterior segment swept‑source OCT and with measurements derived from the CILT software using standardized anterior segment images. Participants are adults scheduled for cataract surgery who meet ocular criteria (axial length 20–25 mm) and who do not have zonulolysis, strabismus, keratoconus, or pseudoexfoliation. Repeated imaging will be performed to assess agreement between the two methods and the reproducibility of each technique. Outcomes include numeric measures of tilt and decentration and statistical agreement metrics such as limits of agreement and intraclass correlation.
Who should consider this trial
Good fit: Ideal candidates are adults scheduled for cataract surgery with axial length between 20 and 25 mm who can comply with imaging visits and do not have zonulolysis, strabismus, keratoconus, or pseudoexfoliation.
Not a fit: Patients with zonulolysis, strabismus, poor compliance, axial length outside 20–25 mm, keratoconus, or pseudoexfoliation (PEX), or those not undergoing cataract surgery, are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the results could help clinicians choose the more reliable imaging method to guide IOL positioning and potentially reduce postoperative visual disturbances.
How similar studies have performed: Anterior segment OCT techniques like CASIA2 are well-established for measuring IOL position, but direct head-to-head comparisons with the CILT calculator are limited, so the approach is partly novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * planned cataract surgery * agreement to participation Exclusion Criteria: * Zonulolysis * Strabismus * Reduced Compliance * Axial length \<20 or \>25 mm * Keratokonus * PEX
Where this trial is running
Vienna, State of Vienna
- Krankenhaus der Barmherzigen Brüder Wien — Vienna, State of Vienna, Austria (Recruiting)
Study contacts
- Study coordinator: Konstantin Seiller-Tarbuk, Dr. med.
- Email: konstantin.seiller@gmail.com
- Phone: 00431211215141
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.