Comparing two methods to measure intraocular lens tilt and decentration
Official title: Agreement and Reproducibility of Intraocular Lens Tilt and Decentration Measurements: A Comparison Between CASIA2 and CILT
Run by St John of God Hospital, Vienna · NCT07025707 · Data updated 2026-11-12
This tests two imaging methods to see which more reliably measures intraocular lens tilt and decentration in people planning cataract surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | St John of God Hospital, Vienna Academic / other |
| Locations | 1 site (Vienna, State of Vienna) |
| Status | Recruiting |
| Started | July 1, 2025 |
| Main results expected | August 1, 2025 |
| Study ends | September 1, 2025 |
| Registry record updated | June 17, 2025 |
| Trial ID | NCT07025707 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults scheduled for cataract surgery with axial length between 20 and 25 mm who can comply with imaging visits and do not have zonulolysis, strabismus, keratoconus, or pseudoexfoliation.
✕Probably not a fit
Patients with zonulolysis, strabismus, poor compliance, axial length outside 20–25 mm, keratoconus, or pseudoexfoliation (PEX), or those not undergoing cataract surgery, are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study compares measurements of intraocular lens (IOL) tilt and decentration obtained with the CASIA2 anterior segment swept‑source OCT and with measurements derived from the CILT software using standardized anterior segment images. Participants are adults scheduled for cataract surgery who meet ocular criteria (axial length 20–25 mm) and who do not have zonulolysis, strabismus, keratoconus, or pseudoexfoliation. Repeated imaging will be performed to assess agreement between the two methods and the reproducibility of each technique. Outcomes include numeric measures of tilt and decentration and statistical agreement metrics such as limits of agreement and intraclass correlation.
Why it matters
Potential benefit: If successful, the results could help clinicians choose the more reliable imaging method to guide IOL positioning and potentially reduce postoperative visual disturbances.
How similar studies have gone: Anterior segment OCT techniques like CASIA2 are well-established for measuring IOL position, but direct head-to-head comparisons with the CILT calculator are limited, so the approach is partly novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * planned cataract surgery * agreement to participation Exclusion Criteria: * Zonulolysis * Strabismus * Reduced Compliance * Axial length \<20 or \>25 mm * Keratokonus * PEX
Where it's running
-
Krankenhaus der Barmherzigen Brüder Wien
Vienna, State of Vienna, Austria Recruiting
Study contacts
- Study coordinator: Konstantin Seiller-Tarbuk, Dr. med.
- Email: konstantin.seiller@gmail.com
- Phone: 00431211215141
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Ultrasound check of IOL tilt after cataract surgery
A noninvasive ultrasound test is used to see if an intraocular lens tilts or decentrates after cataract surgery in adults.
-
Registry of cataract surgery outcomes after phacoemulsification with different intraocular lenses.
This project will collect data to see how people who have phacoemulsification do with different types of intraocular lenses.
-
IOL with a Virtual Aperture for clearer near and distance vision after cataract surgery
A device study tests whether a virtual aperture intraocular lens can help adults with cataracts see clearly at distances and near without glasses.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.